• INCLUSION CRITERIA:

Subjects will be able to enroll if they:

1. Have the ability to understand and sign an informed consent.
2. Are able and willing to give a blood sample.

3. Have a clinical diagnosis of diabetes based on any one of the following criteria:

   • documented history of plasma glucose value greater than or equal to 210 mg/dl on three different occasions.
   • fasting blood sugar greater than or equal to 150 mg/dl on three different occasions.
   • documented history of ketoacidosis.
   • insulin dependency.
   • documented history of abnormal glucose tolerance test.

EXCLUSION CRITERIA:

Subjects will not be eligible if they:

1. Are under the age of 10.
2. Have impaired decision making capabilities without an authorized designated representative.
3. Have severe systemic disease(s) that compromise our ability to obtain an adequate examination.

4. Have any of the following ocular characteristics or conditions in both eyes:

   • opacities of the ocular media, limitations or pupillary dilation or any other problems sufficient to preclude good, quality stereo fundus photographs.
   • ocular disease which confounds assessment of diabetic retinopathy such as advanced age-related macular degeneration, central serous choroidopathy, optic atrophy, retinal vein occlusion, active uveitis, significant explained or unexplained visual field loss, or any other type of retinopathy or retinal degeneration.
   • chronic requirement for any ocular medication for other diseases, such as glaucoma.