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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005682 |
To conduct incidence and case-control studies of aplastic anemia in metropolitan Bangkok, Thailand
Condition |
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Blood Disease Anemia, Aplastic |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | September 1988 |
Estimated Study Completion Date: | August 1994 |
BACKGROUND:
Aplastic anemia, a form of bone marrow failure, is a disease of largely unknown cause, except for the rare situations involving high doses of radiation. Many agents have been mentioned in case reports to be associated with the development of aplastic anemia and include drugs, chemicals, pesticides, radiation, and viral infection. Of these, chloramphenicol, phenylbutazone, and insecticides are most frequently reported. In the United States and other developed countries the disease prevalence is so low that too few cases occur to make an epidemiological study in a single city logistically feasible. The Bangkok hospitalization rate for aplastic anemia was sufficient to conduct a case-control study. Also, a study conducted in this locale provided information on drugs and chemicals not commonly used in developed countries.
DESIGN NARRATIVE:
All aplastic anemia cases in metropolitan Bangkok were located and verified in the forty hospitals that agreed to participate in the study.
Incidence rates were calculated by age group and sex. In the case-control study, interviews were used to obtain comprehensive histories of drug, chemical, pesticide, radiation, viral infections, and other exposures, along with relevant demographic and medical history information in order to examine the association between and test hypotheses regarding suspected hazards and to estimate the risks of developing aplastic anemia. The basic epidemiologic features of aplastic anemia were described by characterizing these patients in terms of standard demographic variables, age, race, sex, and medical history. The degree of association between viral hepatitis and the development of aplastic anemia was estimated.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 3008 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005682 History of Changes |
Health Authority: | United States: Federal Government |
Aplastic Anemia Hematologic Diseases Anemia, Aplastic Anemia Bone Marrow Diseases |
Hematologic Diseases Anemia, Aplastic Anemia Bone Marrow Diseases |