Full Text View
Tabular View
No Study Results Posted
Related Studies
Monoclonal Antibody Therapy With Sargramostim and Interleukin-2 in Treating Children With Neuroblastoma
This study has been completed.
First Received: May 2, 2000   Last Updated: February 6, 2009   History of Changes
Sponsors and Collaborators: Children's Oncology Group
National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00005576
  Purpose

RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.

Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood. Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. Combining monoclonal antibody therapy with sargramostim or interleukin-2 may kill more tumor cells.

PURPOSE: Phase I trial to study the effectiveness of monoclonal antibody therapy given with sargramostim and interleukin-2 in treating children with neuroblastoma who have just completed bone marrow or peripheral stem cell transplantation.


Condition Intervention Phase
Neuroblastoma
Biological: aldesleukin
Biological: monoclonal antibody Ch14.18
Biological: sargramostim
Drug: isotretinoin
Phase I

MedlinePlus related topics: Cancer Neuroblastoma
Drug Information available for: Granulocyte-macrophage colony-stimulating factor Aldesleukin Sargramostim Immunoglobulins Isotretinoin Globulin, Immune
U.S. FDA Resources
Study Type: Interventional
Study Design: Treatment
Official Title: A PHASE I STUDY OF CHIMERIC HUMAN/MURINE ANTI-GD2 MONOCLONAL ANTIBODY (ch14.18) WITH GM-CSF IN CHILDREN WITH NEUROBLASTOMA AND OTHER GD2 POSITIVE MALIGNANCIES IMMEDIATELY POST AUTOLOGOUS BMT

Further study details as provided by National Cancer Institute (NCI):

Estimated Enrollment: 16
Study Start Date: January 2001
Detailed Description:

OBJECTIVES: I. Determine the maximum tolerated dose of monoclonal antibody (MOAB) Ch14.18 when combined with sargramostim (GM-CSF) and interleukin-2 (IL-2) after autologous bone marrow or peripheral blood stem cell rescue in children with neuroblastoma. II. Determine the toxic effects of this regimen in these patients. III. Determine the pharmacokinetics, including antibody level, antibody-binding activity, and presence of human anti-chimeric antibodies, of this regimen in these patients. IV. Determine the activity of IL-2 and MOAB Ch14.18 against tumor cells in terms of response using standard clinical measurements such as bone marrow immunocytology in these patients. V. Determine the extent of coating of tumor cells (bone marrow metastases) by MOAB Ch14.18 in these patients. VI. Determine the feasibility of isotretinoin administered between courses beginning after course 2 in these patients.

OUTLINE: This is a multicenter, dose-escalation study of monoclonal antibody (MOAB) Ch14.18. Patients receive MOAB Ch14.18 IV over 5 hours on days 7-10 during courses 2 and 4 and on days 3-6 during courses 1, 3, and 5; sargramostim (GM-CSF) IV over 2 hours or subcutaneously daily on days 0-13 during courses 1, 3, and 5; interleukin-2 IV continuously on days 0-3 and 7-10 during courses 2 and 4; and oral isotretinoin twice daily on days 14-27 during courses 2 and 4 and on days 10-23 during courses 3 and 5. Treatment repeats every 24-32 days for 5 courses in the absence of unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of MOAB Ch14.18 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. A minimum of 6 additional patients are treated at the MTD. Patients are followed every other week for 2 months and then every 3 months for 6 months.

PROJECTED ACCRUAL: Approximately 6-16 patients will be accrued for this study within 1 year.

  Eligibility

Ages Eligible for Study:   up to 21 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS: Diagnosis of neuroblastoma based on tumor histology or bone marrow metastasis with elevated urine catecholamine metabolites Confirmation of GD2-positivity not required Must have recently completed a course of myeloablative therapy followed by autologous bone marrow or peripheral blood stem cell (PBSC) rescue May be eligible: After completion of the third course of high-dose chemotherapy with PBSC rescue on protocol CCG-3951 After completion of 1 or more courses of high-dose chemotherapy with PBSC rescue on an institutional (local) protocol Previous treatment on phase I studies (e.g., CCG-3951) allowed Ineligible if evaluable for response on a Phase II/III protocol (e.g., CCG-6921, CCG-3891) Patients who are no longer evaluable for response on a Phase II/III protocol (i.e., disease progression after therapy) are allowed

PATIENT CHARACTERISTICS: Age: 21 and under Performance status: 0-2 Life expectancy: At least 2 months Hematopoietic: Absolute phagocyte count (neutrophils and monocytes) greater than 1,000/mm3 Hepatic: Bilirubin no greater than 1.5 times normal SGOT or SGPT no greater than 5.0 times normal Concurrent veno-occlusive disease allowed if stable or improving Renal: Creatinine no greater than 1.5 times normal OR Creatinine clearance or radioisotope glomerular filtration rate at least 60 mL/min Cardiovascular: Shortening fraction at least 27% by echocardiogram OR Ejection fraction greater than 50% by MUGA scan Pulmonary: FEV1 and FVC greater than 60% predicted OR For children who cannot perform pulmonary function tests: No evidence of dyspnea at rest No exercise intolerance Oxygen saturation greater than 94% on room air by pulse oximetry Other: No CNS toxicity greater than grade 1 Concurrent seizure disorder allowed if on anticonvulsants and well controlled

PRIOR CONCURRENT THERAPY: Biologic Therapy: See Disease Characteristics No prior monoclonal antibody (MOAB) 14G2A or MOAB Ch14.18 No other concurrent cytokines or growth factors (e.g., interferon or filgrastim (G-CSF)) Chemotherapy: See Disease Characteristics At least 2 weeks since prior myelosuppressive chemotherapy No other concurrent anticancer chemotherapy Endocrine therapy: At least 2 weeks since prior corticosteroids No concurrent corticosteroids Radiotherapy: At least 7 days since prior radiotherapy No concurrent radiotherapy except for localized painful lesions Surgery: Not specified Other: At least 2 weeks since prior immunosuppressive drugs At least 2 weeks since prior tretinoin No concurrent immunosuppressive drugs (e.g., cyclosporine) No concurrent pentoxifylline

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00005576

  Show 54 Study Locations
Sponsors and Collaborators
Children's Oncology Group
Investigators
Study Chair: Andrew L. Gilman, MD Children's Mercy Hospital
  More Information

Additional Information:
Publications:
Study ID Numbers: CDR0000063533, COG-A0935A, CCG-0935, CCG-0935A
Study First Received: May 2, 2000
Last Updated: February 6, 2009
ClinicalTrials.gov Identifier: NCT00005576     History of Changes
Health Authority: United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
regional neuroblastoma
disseminated neuroblastoma
recurrent neuroblastoma

Study placed in the following topic categories:
Anti-HIV Agents
Neuroectodermal Tumors, Primitive
Immunologic Factors
Antiviral Agents
Neuroblastoma
Recurrence
Antibodies, Monoclonal
Neuroectodermal Tumors
Antibodies
Aldesleukin
Anti-Retroviral Agents
Interleukin-2
Neoplasms, Germ Cell and Embryonal
Isotretinoin
Neuroepithelioma
Neuroectodermal Tumors, Primitive, Peripheral
Neoplasms, Glandular and Epithelial
Immunoglobulins

Additional relevant MeSH terms:
Anti-Infective Agents
Anti-HIV Agents
Neuroectodermal Tumors, Primitive
Neoplasms by Histologic Type
Immunologic Factors
Antineoplastic Agents
Physiological Effects of Drugs
Neoplasms, Nerve Tissue
Antiviral Agents
Pharmacologic Actions
Neuroblastoma
Antibodies, Monoclonal
Neuroectodermal Tumors
Neoplasms
Antibodies
Aldesleukin
Anti-Retroviral Agents
Therapeutic Uses
Neoplasms, Germ Cell and Embryonal
Isotretinoin
Neoplasms, Neuroepithelial
Dermatologic Agents
Neuroectodermal Tumors, Primitive, Peripheral
Neoplasms, Glandular and Epithelial

ClinicalTrials.gov processed this record on May 07, 2009