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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005525 |
To conduct a genetic analysis of anatomic risk factors for sleep apnea in a well-characterized United States population-based registry of elderly male twins who have been successfully followed for the past 30 years.
Condition |
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Lung Diseases Sleep Apnea Syndromes Obesity |
Study Type: | Observational |
Study Design: | Natural History, Defined Population |
Study Start Date: | August 1998 |
Estimated Study Completion Date: | July 2002 |
BACKGROUND:
The contribution of genetic factors to sleep disorders has been demonstrated in twin and family studies, and further understanding of the genetic underpinning of sleep disorders is considered an important area of research. Many of the suggested risk factors for sleep apnea (e.g.,craniofacial morphology, obesity) have genetic determinants. However, a formal genetic analysis of these anatomical risk factors with sleep-recorded physiological measurements has not so far been conducted.
DESIGN NARRATIVE:
The investigators recruited a subsample of pairs from the NAS-NRC World War II Twin Registry in which at least one of the twin brothers reported sleep apnea symptoms and a subsample of control pairs in which both twins reported no symptoms. They monitoring the subgroup of twin pairs with overnight sleep recording. They also collected anthropometric measurements of weight, height, neck circumference, and craniofacial morphology and blood samples for determination of zygosity and DNA extraction for future molecular studies.
The twin design is most powerful for estimating the genetic and/or environmental overlap between physiological measurements such as sleep-recorded disordered breathing, obesity, and craniofacial morphology. The investigators chose to focus on an elderly male twin sample for which a wealth of data relevant to this study had been previously collected. Twin pair concordance or discordance for monitored sleep-disordered breathing allowed the full characterization of genetic/familial and individual environmental factors associated with the expression and severity of this condition.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 5053 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005525 History of Changes |
Health Authority: | United States: Federal Government |
Obesity Sleep Apnea Syndromes Apnea Respiration Disorders Dyssomnias Sleep Disorders Overweight Sleep Disorders, Intrinsic |
Body Weight Signs and Symptoms Respiratory Tract Diseases Lung Diseases Signs and Symptoms, Respiratory Nutrition Disorders Overnutrition |
Obesity Sleep Apnea Syndromes Disease Apnea Nervous System Diseases Respiration Disorders Sleep Disorders Dyssomnias Overweight Sleep Disorders, Intrinsic |
Body Weight Signs and Symptoms Pathologic Processes Respiratory Tract Diseases Lung Diseases Syndrome Signs and Symptoms, Respiratory Nutrition Disorders Overnutrition |