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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005412 |
To examine the role of dietary antioxidants in the etiology of atherosclerosis in both sexes and in whites and Blacks.
Condition |
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Atherosclerosis Cardiovascular Diseases Heart Diseases Carotid Stenosis |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | July 1992 |
Estimated Study Completion Date: | June 1995 |
BACKGROUND:
Atherosclerosis is this nation's leading cause of death for males and females, and Blacks and whites. There is mounting evidence that the oxidation of blood low density lipoproteins (LDL) plays an important role in the pathogenesis of this disease. LDL oxidation can be prevented by several dietary antioxidants, in particular, vitamin C, vitamin E, and beta-carotene. There is preliminary evidence that dietary antioxidants may slow the natural history of atherosclerosis in humans. Until now studies in this area have included predominantly white males with symptomatic disease.
DESIGN NARRATIVE:
The case-control study used data collected in ARIC to test the hypothesis that individuals in the lowest quintile of vitamin C, vitamin E and carotenoid consumption were at higher risk of asymptomatic atherosclerosis than those consuming greater amounts. Antioxidant intake was assessed by a validated food frequency questionnaire and a diet supplement survey. Cases were those with asymptomatic carotid artery atherosclerosis as determined by B-mode ultrasonography. Controls were those without evidence of carotid artery atherosclerosis. Secondary analyses determined which sex-race subgroups were at particular risk due to low antioxidant consumption.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 4330 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005412 History of Changes |
Health Authority: | United States: Federal Government |
Arterial Occlusive Diseases Atherosclerosis Carotid Stenosis Antioxidants Heart Diseases Vascular Diseases |
Central Nervous System Diseases Constriction, Pathologic Arteriosclerosis Brain Diseases Carotid Artery Diseases Cerebrovascular Disorders |
Arterial Occlusive Diseases Atherosclerosis Carotid Stenosis Heart Diseases Nervous System Diseases Vascular Diseases |
Central Nervous System Diseases Cardiovascular Diseases Arteriosclerosis Brain Diseases Carotid Artery Diseases Cerebrovascular Disorders |