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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005408 |
To reanalyze data on risk factors for cardiovascular disease (CVD) including total cholesterol and high density lipoprotein (HDL) cholesterol for the subjects in the first, second, and third exams of the NHLBI Twin Study.
Condition |
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Cardiovascular Diseases Heart Diseases Atherosclerosis |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | July 1992 |
Estimated Study Completion Date: | April 1994 |
BACKGROUND:
The results of these longitudinal analyses yielded new insights on genetic effects affecting CVD risk factors during the aging process.
DESIGN NARRATIVE:
The analyses utilized maximum likelihood estimators of genetic variance which were asymptotically more efficient than the method-of-moments estimators used in previous analyses. The models used incorporated terms to partition the variance in a trait from twin data into either i) additive genetic variance and unshared environmental variance (the AE model), ii) additive genetic variance, dominance genetic variance, and unshared environmental variance (the ADE model), or iii) additive genetic variance, shared environmental variance, and unshared environmental variance (the ACE model). The AE, ADE, and ACE models were fitted separately to data from each of the three exams to obtain a cross-sectional analysis. The investigators also extended these models for use with longitudinal data by incorporating terms to represent the covariance of variance components from different exams.
Two important additional objectives of this study were i) to introduce resistant estimation techniques in twin modeling, which trimmed the effect of outlier data points smoothly, and ii) to carefully study the performance of maximum likelihood and method-of-moments estimators when assumptions of the twin model were violated. The results of these parts of the study should yield a more complete understanding of the relative merits and limitations of twin modeling procedures.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 4326 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005408 History of Changes |
Health Authority: | United States: Federal Government |
Arterial Occlusive Diseases Atherosclerosis Heart Diseases Vascular Diseases Arteriosclerosis |
Arterial Occlusive Diseases Atherosclerosis Heart Diseases |
Vascular Diseases Cardiovascular Diseases Arteriosclerosis |