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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005378 |
To test the hypothesis that clinically inapparent sleep-disordered breathing was associated with blood pressure elevation, impairment of health-related quality of life, and depression.
Condition |
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Cardiovascular Diseases Hypertension Depression Sleep Apnea Syndromes Lung Diseases |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | July 1994 |
Estimated Study Completion Date: | May 1998 |
BACKGROUND:
The health impact of disordered breathing during sleep among middle-aged and older men and women in the general population had not been well studied, and the need for treating relatively mild degrees of sleep-disordered breathing was unknown in 1994. The study was the first population study which examined the effect of sleep-disordered breathing on these health outcomes. The study sought to establish the prevalence of clinically important sleep-disordered breathing among middle-aged and older men and women and to provide quantitative data to serve as the basis for selecting patients for screening and deciding which patients might benefit from therapeutic intervention.
DESIGN NARRATIVE:
The study evaluated the hypothesis that clinically inapparent sleep-disordered breathing was associated with blood pressure elevation, impairment of health-related quality of life, and depression. The study used the Veterans Administration Normative Aging Study (NAS) population, which consisted of approximately 1,700 community-dwelling-men who returned for examination every three years. Respiratory function was assessed during sleep among these men and their wives using a validated method for home sleep monitoring. Blood pressure, health-related quality of life, and depression score were also assessed in the home. The potential associations of sleep-disordered breathing with hypertension, impaired health-related quality of life, and depression were evaluated, and the possibility that these relationships differed between men and women was examined.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 4276 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005378 History of Changes |
Health Authority: | United States: Federal Government |
Sleep Apnea Syndromes Depression Apnea Respiration Disorders Vascular Diseases Sleep Disorders Dyssomnias |
Depressive Disorder Behavioral Symptoms Sleep Disorders, Intrinsic Respiratory Tract Diseases Lung Diseases Hypertension |
Sleep Apnea Syndromes Disease Depression Apnea Nervous System Diseases Respiration Disorders Vascular Diseases Sleep Disorders Dyssomnias |
Behavioral Symptoms Sleep Disorders, Intrinsic Pathologic Processes Respiratory Tract Diseases Lung Diseases Syndrome Cardiovascular Diseases Hypertension |