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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005309 |
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.
Condition |
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Acquired Immunodeficiency Syndrome HIV Infections Blood Disease Hemophilia A Hepatitis, Viral, Human Blood Transfusion Cytomegalovirus Infections |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | July 1990 |
Estimated Study Completion Date: | March 1995 |
BACKGROUND:
In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.
DESIGN NARRATIVE:
Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 3012 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005309 History of Changes |
Health Authority: | United States: Federal Government |
Liver Diseases Sexually Transmitted Diseases, Viral Hematologic Diseases Blood Coagulation Disorders Acquired Immunodeficiency Syndrome Hemophilia A Hepatitis, Viral, Human Hemostatic Disorders Cytomegalovirus Immunologic Deficiency Syndromes Herpesviridae Infections |
Hepatitis Virus Diseases Digestive System Diseases Hemorrhagic Disorders Genetic Diseases, Inborn HIV Infections Sexually Transmitted Diseases Cytomegalic Inclusion Disease Cytomegalovirus Infections DNA Virus Infections Retroviridae Infections |
Communicable Diseases Liver Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Hemophilia A Hepatitis, Viral, Human Infection Pathologic Processes Hemorrhagic Disorders Syndrome Cytomegalovirus Infections Retroviridae Infections RNA Virus Infections Disease Immune System Diseases |
Hematologic Diseases Coagulation Protein Disorders Blood Coagulation Disorders Acquired Immunodeficiency Syndrome Immunologic Deficiency Syndromes Herpesviridae Infections Hepatitis Virus Diseases Digestive System Diseases Blood Coagulation Disorders, Inherited Genetic Diseases, Inborn HIV Infections Sexually Transmitted Diseases Lentivirus Infections DNA Virus Infections |