Natural History of Post-Transfusion Non-A, Non-B Hepatitis

This study has been completed.

First Received: May 25, 2000 Last Updated: June 23, 2005 History of Changes

Sponsored by:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:	NCT00005306

Purpose

To compare the clinical, biochemical, and histological status of Non-A, Non-B post-transfusion hepatitis patients with that of patients who did not develop post-transfusion hepatitis.

Condition
Hepatitis, Viral, Human Blood Transfusion Liver Diseases

MedlinePlus related topics: Blood Transfusion and Donation Hepatitis Liver Diseases

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	March 1988
Estimated Study Completion Date:	September 2001

Show Detailed Description

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005306

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

Investigator:

Leonard Seeff

Georgetown University

More Information

Publications:

Seeff LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter HJ, Iber FL, Hollinger FB, Gitnick G, Knodell RG, Perrillo RP, et al. Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. N Engl J Med. 1992 Dec 31;327(27):1906-11.

Duffy LF, Kerzner B, Seeff L, Barr SB, Soldin SJ. Preliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver function. Clin Biochem. 1995 Oct;28(5):527-30.

Koff RS, Seeff LB. Economic modeling of treatment in chronic hepatitis B and chronic hepatitis C: promises and limitations. Hepatology. 1995 Dec;22(6):1880-2. No abstract available.

Tedeschi V, Seeff LB. Diagnostic tests for hepatitis C: where are we now? Ann Intern Med. 1995 Sep 1;123(5):383-5. No abstract available.

Seeff LB. Natural history of viral hepatitis, type C. Semin Gastrointest Dis. 1995 Jan;6(1):20-7. Review. No abstract available.

Seeff LB, Alter HJ. Spousal transmission of the hepatitis C virus? Ann Intern Med. 1994 May 1;120(9):807-9. No abstract available.

Norman JE, Beebe GW, Hoofnagle JH, Seeff LB. Mortality follow-up of the 1942 epidemic of hepatitis B in the U.S. Army. Hepatology. 1993 Oct;18(4):790-7.

Seeff LB, Hollinger FB, Alter HJ, Wright EC, Cain CM, Buskell ZJ, Ishak KG, Iber FL, Toro D, Samanta A, Koretz RL, Perrillo RP, Goodman ZD, Knodell RG, Gitnick G, Morgan TR, Schiff ER, Lasky S, Stevens C, Vlahcevic RZ, Weinshel E, Tanwandee T, Lin HJ, Barbosa L. Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative study. Hepatology. 2001 Feb;33(2):455-63.

Lin HJ, Seeff LB, Barbosa L, Hollinger FB. Occurrence of identical hypervariable region 1 sequences of hepatitis C virus in transfusion recipients and their respective blood donors: divergence over time. Hepatology. 2001 Aug;34(2):424-9.

Harris DR, Gonin R, Alter HJ, Wright EC, Buskell ZJ, Hollinger FB, Seeff LB. The relationship of acute transfusion-associated hepatitis to the development of cirrhosis in the presence of alcohol abuse. Ann Intern Med. 2001 Jan 16;134(2):120-4.

Study ID Numbers:	3007
Study First Received:	May 25, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00005306 History of Changes
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Virus Diseases
Hepatitis
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human

Additional relevant MeSH terms:

Virus Diseases
Hepatitis
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human

ClinicalTrials.gov processed this record on May 07, 2009