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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005266 |
To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that allowed for censored observations of outcomes, environmental covariates, and unmeasured genotype-environment interactions.
Condition |
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Cardiovascular Diseases Heart Diseases Hypertension Diabetes Mellitus Obesity Coronary Disease Myocardial Ischemia |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | September 1990 |
Estimated Study Completion Date: | September 1992 |
BACKGROUND:
Methodologically, statistical methods in genetics and epidemiology have developed largely independently; and as a result, there seemed to be little communication between the two fields. Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields. The method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable, multiple and continuous environmental risk factors, and correlation in outcomes between related individuals.
The study was supported by the Small Grants Program established by the National Heart, Lung, and Blood Institute in January 1990 to extend analyses of research data generated by clinical trials, population research, and demonstration and education studies.
DESIGN NARRATIVE:
Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking, diet, weight changes, physical activity, and socioeconomic variables. The contributions of genetic and environmental factors to twin similarities in health behavior were also examined.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 1150 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005266 History of Changes |
Health Authority: | United States: Federal Government |
Arterial Occlusive Diseases Obesity Heart Diseases Metabolic Diseases Myocardial Ischemia Diabetes Mellitus Vascular Diseases Endocrine System Diseases Overweight Ischemia Arteriosclerosis |
Body Weight Coronary Disease Signs and Symptoms Nutrition Disorders Overnutrition Endocrinopathy Glucose Metabolism Disorders Metabolic Disorder Coronary Artery Disease Hypertension |
Arterial Occlusive Diseases Obesity Metabolic Diseases Heart Diseases Myocardial Ischemia Diabetes Mellitus Vascular Diseases Endocrine System Diseases Overweight Ischemia Arteriosclerosis |
Body Weight Coronary Disease Signs and Symptoms Pathologic Processes Nutrition Disorders Overnutrition Cardiovascular Diseases Glucose Metabolism Disorders Coronary Artery Disease Hypertension |