Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
---|---|
Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005250 |
To screen by electrocardiography the entire population of 1,400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome (LQTS).
Condition |
---|
Heart Diseases Cardiovascular Diseases Tachycardia, Ventricular Ventricular Fibrillation Long QT Syndrome |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | January 1990 |
Estimated Study Completion Date: | December 1992 |
BACKGROUND:
LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation. The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population.
DESIGN NARRATIVE:
The entire population was screened to identify cases of LQTS. In addition, 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes. The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 1132 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005250 History of Changes |
Health Authority: | United States: Federal Government |
Paroxysmal Ventricular Fibrillation Heart Diseases Cardiovascular Abnormalities Tachycardia Long QT Syndrome |
Congenital Abnormalities Heart Defects, Congenital Tachycardia, Ventricular Ventricular Fibrillation Arrhythmias, Cardiac |
Heart Diseases Disease Cardiovascular Abnormalities Tachycardia Pathologic Processes Syndrome Cardiovascular Diseases |
Long QT Syndrome Congenital Abnormalities Tachycardia, Ventricular Heart Defects, Congenital Ventricular Fibrillation Arrhythmias, Cardiac |