Linkage Study of Long QT Syndrome In An Amish Kindred

This study has been completed.

First Received: May 25, 2000 Last Updated: June 23, 2005 History of Changes

Sponsored by:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:	NCT00005250

Purpose

To screen by electrocardiography the entire population of 1,400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome (LQTS).

Condition
Heart Diseases Cardiovascular Diseases Tachycardia, Ventricular Ventricular Fibrillation Long QT Syndrome

Genetics Home Reference related topics: Andersen-Tawil syndrome Brugada syndrome Jervell and Lange-Nielsen syndrome Romano-Ward syndrome short QT syndrome

MedlinePlus related topics: Heart Diseases

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	January 1990
Estimated Study Completion Date:	December 1992

Detailed Description:

BACKGROUND:

LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation. The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population.

DESIGN NARRATIVE:

The entire population was screened to identify cases of LQTS. In addition, 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes. The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS.

Eligibility

Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

No Contacts or Locations Provided

More Information

No publications provided

Study ID Numbers:	1132
Study First Received:	May 25, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00005250 History of Changes
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Paroxysmal Ventricular Fibrillation
Heart Diseases
Cardiovascular Abnormalities
Tachycardia
Long QT Syndrome

Congenital Abnormalities
Heart Defects, Congenital
Tachycardia, Ventricular
Ventricular Fibrillation
Arrhythmias, Cardiac

Additional relevant MeSH terms:

Heart Diseases
Disease
Cardiovascular Abnormalities
Tachycardia
Pathologic Processes
Syndrome
Cardiovascular Diseases

Long QT Syndrome
Congenital Abnormalities
Tachycardia, Ventricular
Heart Defects, Congenital
Ventricular Fibrillation
Arrhythmias, Cardiac

ClinicalTrials.gov processed this record on May 07, 2009