Full Text View
Tabular View
No Study Results Posted
Related Studies
Triggers of Ventricular Arrhythmias (TOVA) Study
This study has been completed.
First Received: May 25, 2000   Last Updated: January 3, 2006   History of Changes
Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00005243
  Purpose

To investigate factors which trigger the discharge of implantable cardioverter-defibrillators (ICDs).


Condition
Cardiovascular Diseases
Arrhythmia
Myocardial Infarction
Heart Diseases

Genetics Home Reference related topics: Brugada syndrome short QT syndrome
MedlinePlus related topics: Arrhythmia Heart Attack Heart Diseases
U.S. FDA Resources
Study Type: Observational
Study Design: Natural History

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: April 1989
Estimated Study Completion Date: August 2004
  Show Detailed Description

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00005243

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Investigator: James Muller Massachusetts General Hospital
  More Information

Publications:
Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991 Jan 15;133(2):144-53.
Maclure M. Multivariate refutation of aetiological hypotheses in non-experimental epidemiology. Int J Epidemiol. 1990 Dec;19(4):782-7. Review.
Mittleman MA. Estimation of exposure prevalence in a population at risk using data from cases and an external estimate of the relative risk. Epidemiology. 1995 Sep;6(5):551-3.
Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, Friedman R, Benson H, Muller JE. Triggering of acute myocardial infarction onset by episodes of anger. Determinants of Myocardial Infarction Onset Study Investigators. Circulation. 1995 Oct 1;92(7):1720-5.
Mittleman MA, Maclure M, Robins JM. Control sampling strategies for case-crossover studies: an assessment of relative efficiency. Am J Epidemiol. 1995 Jul 1;142(1):91-8.
Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators. N Engl J Med. 1993 Dec 2;329(23):1677-83.
Verrier RL, Mittelman MA. Cardiovascular consequences of anger and other stress states. Baillieres Clin Neurol. 1997 Jul;6(2):245-59. Review.
Mittleman MA, Maclure M, Nachnani M, Sherwood JB, Muller JE. Educational attainment, anger, and the risk of triggering myocardial infarction onset. The Determinants of Myocardial Infarction Onset Study Investigators. Arch Intern Med. 1997 Apr 14;157(7):769-75.
Verrier RL, Muller JE, Hobson JA. Sleep, dreams, and sudden death: the case for sleep as an autonomic stress test for the heart. Cardiovasc Res. 1996 Feb;31(2):181-211. Review. No abstract available.
Verrier RL, Mittleman MA. Life-threatening cardiovascular consequences of anger in patients with coronary heart disease. Cardiol Clin. 1996 May;14(2):289-307. Review.
Mittleman MA, Siscovick DS. Physical exertion as a trigger of myocardial infarction and sudden cardiac death. Cardiol Clin. 1996 May;14(2):263-70. Review.
Muller JE, Mittleman A, Maclure M, Sherwood JB, Tofler GH. Triggering myocardial infarction by sexual activity. Low absolute risk and prevention by regular physical exertion. Determinants of Myocardial Infarction Onset Study Investigators. JAMA. 1996 May 8;275(18):1405-9.
Mittleman MA. Estimation of exposure prevalence in a population at risk using data from cases and an external estimate of the relative risk. Epidemiology. 1995 Sep;6(5):551-3.
Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, Friedman R, Benson H, Muller JE. Triggering of acute myocardial infarction onset by episodes of anger. Determinants of Myocardial Infarction Onset Study Investigators. Circulation. 1995 Oct 1;92(7):1720-5.
Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Lack of effect of recent alcohol consumption on the course of acute myocardial infarction. Am Heart J. 1999 Nov;138(5 Pt 1):926-33.
Mittleman MA, Mintzer D, Maclure M, Tofler GH, Sherwood JB, Muller JE. Triggering of myocardial infarction by cocaine. Circulation. 1999 Jun 1;99(21):2737-41.
Mukamal KJ, Mittleman MA, Maclure M, Sherwood JB, Goldberg RJ, Muller JE. Recent aspirin use is associated with smaller myocardial infarct size and lower likelihood of Q-wave infarction. Am Heart J. 1999 Jun;137(6):1120-8.
Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Increased risk of congestive heart failure among infarctions with nighttime onset. Am Heart J. 2000 Sep;140(3):438-42.
Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Prior alcohol consumption and mortality following acute myocardial infarction. JAMA. 2001 Apr 18;285(15):1965-70.
Mukamal KJ, Nesto RW, Cohen MC, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction. Diabetes Care. 2001 Aug;24(8):1422-7.
Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE. Triggering myocardial infarction by marijuana. Circulation. 2001 Jun 12;103(23):2805-9.
Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Evaluation of sex-related differences in survival after hospitalization for acute myocardial infarction. Am J Cardiol. 2001 Oct 1;88(7):768-71. No abstract available.
Mukamal KJ, Maclure M, Sherwood JB, Kannam JP, Muller JE, Mittleman MA. Height is not associated with long-term survival after acute myocardial infarction. Am Heart J. 2001 Nov;142(5):852-6.
Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Tea consumption and mortality after acute myocardial infarction. Circulation. 2002 May 28;105(21):2476-81.
Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Variation in the risk of onset of acute myocardial infarction during the menstrual cycle. Am J Cardiol. 2002 Jul 1;90(1):49-51. No abstract available.
Mukamal KJ, Muller JE, Walkoff DS, Maclure M, Sherwood JB, Mittleman MA. Comparison of courses of patients with acute myocardial infarction with chest pain appearing during exertion versus those with chest pain not occurring during exertion. Am J Cardiol. 2002 Sep 15;90(6):642-5. No abstract available.
Rana JS, Mukamal KJ, Morgan JP, Muller JE, Mittleman MA. Circadian variation in the onset of myocardial infarction: effect of duration of diabetes. Diabetes. 2003 Jun;52(6):1464-8.
Whang W, Mittleman MA, Rich DQ, Wang PJ, Ruskin JN, Tofler GH, Muller JE, Albert CM; TOVA Investigators. Heart failure and the risk of shocks in patients with implantable cardioverter defibrillators: results from the Triggers Of Ventricular Arrhythmias (TOVA) study. Circulation. 2004 Mar 23;109(11):1386-91. Epub 2004 Mar 01.
Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Caffeinated coffee consumption and mortality after acute myocardial infarction. Am Heart J. 2004 Jun;147(6):999-1004.
Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Educational attainment and myocardial infarct-related congestive heart failure (the Determinants of Myocardial Infarction Onset Study). Am J Cardiol. 2004 May 15;93(10):1288-91.
Rana JS, Mukamal KJ, Morgan JP, Muller JE, Mittleman MA. Obesity and the risk of death after acute myocardial infarction. Am Heart J. 2004 May;147(5):841-6.
Whang W, Albert CM, Sears SF Jr, Lampert R, Conti JB, Wang PJ, Singh JP, Ruskin JN, Muller JE, Mittleman MA; TOVA Study Investigators. Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators: results from the Triggers of Ventricular Arrhythmias (TOVA) study. J Am Coll Cardiol. 2005 Apr 5;45(7):1090-5.
Mukamal KJ, Maclure M, Muller JE, Mittleman MA. Binge drinking and mortality after acute myocardial infarction. Circulation. 2005 Dec 20;112(25):3839-45.

Study ID Numbers: 1124
Study First Received: May 25, 2000
Last Updated: January 3, 2006
ClinicalTrials.gov Identifier: NCT00005243     History of Changes
Health Authority: United States: Federal Government

Study placed in the following topic categories:
Necrosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases
 Ischemia
Infarction
Myocardial Infarction
Arrhythmias, Cardiac

Additional relevant MeSH terms:
Necrosis
Pathologic Processes
Heart Diseases
Myocardial Ischemia
Vascular Diseases
 Cardiovascular Diseases
Ischemia
Infarction
Myocardial Infarction
Arrhythmias, Cardiac

ClinicalTrials.gov processed this record on May 07, 2009



U.S. National Library of Medicine,  Contact Help Desk
U.S. National Institutes of Health,  U.S. Department of Health & Human Services,
USA.gov,  Copyright,  Privacy,  Accessibility,  Freedom of Information Act

U.S. National Institutes of Health U.S. National Library of Medicine U.S. Department of Health & Human Services