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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00005173 |
To evaluate whether the long-term use of oral contraceptives, after discontinuation, was associated with an increased incidence of first nonfatal myocardial infarction among women above the age of 50.
Condition |
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Cardiovascular Diseases Coronary Disease Myocardial Infarction Heart Diseases Menopause Postmenopause |
Study Type: | Observational |
Study Design: | Natural History |
Study Start Date: | April 1985 |
Estimated Study Completion Date: | April 1989 |
BACKGROUND:
In the mid 1980s, it was known that current oral contraceptive use (in the preceding month) increased the risk of myocardial infarction three to four-fold. Evidence seemed to indicate that past use lasting a total of five or more years was associated with a residual two-fold increase in myocardial infarction risk among women 40 to 49 years old. Since the incidence of the disease started to become appreciable beyond age 49, it was of public health importance to reexamine the evidence in a data base which included women aged 50 or older to determine how long the increased risk persisted and whether it varied according to the formulation of the preparation used. An increase in risk that persisted after discontinuation of oral contraceptive use would have major public health implications since millions of women have used or will use oral contraceptives for long periods.
DESIGN NARRATIVE:
The design was that of a case-control study. Cases were identified by weekly telephone calls to the coronary care units of 78 hospitals in greater Boston, Southern Connecticut, and Westchester County. Nurse-interviewers administered standard interviews to cases convalescing on medical wards after discharge from coronary care units and to controls identified in the same hospitals. Histories of oral contraceptive use, including the timing and duration of use and the name of the preparations, were recorded along with information on other drug use and myocardial infarction risk factors such as cigarette smoking. Data were collected for three years.
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
No eligibility criteria
Study ID Numbers: | 1048 |
Study First Received: | May 25, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005173 History of Changes |
Health Authority: | United States: Federal Government |
Arterial Occlusive Diseases Heart Diseases Contraceptive Agents Myocardial Ischemia Contraceptives, Oral Contraceptive Agents, Female Vascular Diseases Ischemia |
Arteriosclerosis Coronary Disease Necrosis Infarction Myocardial Infarction Coronary Artery Disease Menopause |
Arterial Occlusive Diseases Heart Diseases Contraceptive Agents Myocardial Ischemia Physiological Effects of Drugs Contraceptives, Oral Contraceptive Agents, Female Vascular Diseases Reproductive Control Agents Arteriosclerosis |
Ischemia Pharmacologic Actions Coronary Disease Necrosis Pathologic Processes Therapeutic Uses Cardiovascular Diseases Infarction Myocardial Infarction Coronary Artery Disease |