Generation of Anti-HCV Antibodies From Bone Marrow: Defining the Repertoire of Immune Response to HCV Quasispecies - Full Text View

Sponsored by:	National Institutes of Health Clinical Center (CC)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00004851

Purpose

To generate a library of genes that reflect the entirety of antibody responses to hepatitis C virus (HCV) made during the 20-year course of HCV infection in a single patient (WH) whose viral quasispecies has been extensively characterized. In addition to characterizing the sequential events in antibody formation and their relationship to the changing pattern of viral quasispecies, we hope to identify neutralizing antibodies and the epitopes to which they are directed. Ultimately we seek to gain insight into the host mechanisms that suppress viral replication and to translate this to therapeutic and preventive modalities.

Condition
Hepatitis C

MedlinePlus related topics: Hepatitis Hepatitis C

Drug Information available for: Immunoglobulins Globulin, Immune

U.S. FDA Resources

Study Type:	Observational
Official Title:	Generation of Anti-HCV Antibodies From Bone Marrow: Defining the Repertoire of Immune Response to HCV Quasispecies

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	1
Study Start Date:	April 1999
Estimated Study Completion Date:	May 2001

Detailed Description:

To generate a library of genes that reflect the entirety of antibody responses to hepatitis C virus (HCV) made during the 20-year course of HCV infection in a single patient (WH) whose viral quasispecies has been extensively characterized. In addition to characterizing the sequential events in antibody formation and their relationship to the changing pattern of viral quasispecies, we hope to identify neutralizing antibodies and the epitopes to which they are directed. Ultimately we seek to gain insight into the host mechanisms that suppress viral replication and to translate this to therapeutic and preventive modalities.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Persistent infection with mild hepatitis that is non-progressive.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004851

Locations

United States, Maryland
Warren G. Magnuson Clinical Center (CC)
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institutes of Health Clinical Center (CC)

More Information

Publications:

Feinstone SM, Alter HJ, Dienes HP, Shimizu Y, Popper H, Blackmore D, Sly D, London WT, Purcell RH. Non-A, non-B hepatitis in chimpanzees and marmosets. J Infect Dis. 1981 Dec;144(6):588-98.

Hijikata M, Shimizu YK, Kato H, Iwamoto A, Shih JW, Alter HJ, Purcell RH, Yoshikura H. Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes. J Virol. 1993 Apr;67(4):1953-8.

Shimizu YK, Hijikata M, Iwamoto A, Alter HJ, Purcell RH, Yoshikura H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol. 1994 Mar;68(3):1494-500.

Study ID Numbers:	990090, 99-CC-0090
Study First Received:	March 2, 2000
Last Updated:	March 3, 2008
ClinicalTrials.gov Identifier:	NCT00004851 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

HCV Antibody Library

Study placed in the following topic categories:

Virus Diseases
Hepatitis
Antibodies
Liver Diseases
Digestive System Diseases

Immunologic Factors
Hepatitis, Viral, Human
Hepatitis C Antibodies
Hepatitis C
Immunoglobulins

Additional relevant MeSH terms:

Liver Diseases
RNA Virus Infections
Flaviviridae Infections
Immunologic Factors
Physiological Effects of Drugs
Hepatitis, Viral, Human
Pharmacologic Actions

Hepatitis
Virus Diseases
Antibodies
Digestive System Diseases
Hepatitis C
Hepatitis C Antibodies

ClinicalTrials.gov processed this record on May 07, 2009