Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups

This study has been completed.

First Received: February 24, 2000 Last Updated: June 23, 2005 History of Changes

Sponsors and Collaborators:	National Institute of Dental and Craniofacial Research (NIDCR) Columbia University
Information provided by:	Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:	NCT00004781

Purpose

OBJECTIVES: I. Evaluate the development of oral manifestations of human immunodeficiency virus infection in relationship to the onset of immunologic alterations and systemic symptoms in different risk groups: gay/bisexual men, male intravenous drug users, and female intravenous drug users.

II. Evaluate the immune and inflammatory response to periodontal and other microbial pathogens.

III. Evaluate the bacterial species infecting the oral cavity in patients in these risk groups.

Condition
HIV Infections Candidiasis, Oral

MedlinePlus related topics: AIDS Yeast Infections

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment:	250
Study Start Date:	September 1989

Detailed Description:

PROTOCOL OUTLINE:

Patients undergo a periodontal assessment every 6 months until medically unable to continue. The oral/dental exam includes saliva and gingival crevicular fluid analysis and, as indicated, oral photographs.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Human immunodeficiency virus infection (HIV) seropositive or seronegative At risk for HIV, i.e.: Gay/bisexual men Male intravenous drug users Female intravenous drug users No acquired immunodeficiency syndrome Currently enrolled in Columbia Presbyterian Medical Center protocol "The Natural History and Progression of HIV Infection"

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004781

Sponsors and Collaborators

National Institute of Dental and Craniofacial Research (NIDCR)

Columbia University

Investigators

Study Chair:

Ira B. Lamster

Columbia University

More Information

No publications provided

Study ID Numbers:	199/11861, CU-SDOS-5059
Study First Received:	February 24, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00004781 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by Office of Rare Diseases (ORD):

HIV-associated candidiasis
candidiasis
disease-related problem/condition
fungal infection

immunologic disorders and infectious disorders
infection
rare disease

Study placed in the following topic categories:

Mouth Diseases
Candidiasis, Oral
Sexually Transmitted Diseases, Viral
Candidiasis
Acquired Immunodeficiency Syndrome
Rare Diseases
Immunologic Deficiency Syndromes

Virus Diseases
Mycoses
Oral Manifestations
HIV Infections
Sexually Transmitted Diseases
Stomatognathic Diseases
Retroviridae Infections

Additional relevant MeSH terms:

Mouth Diseases
Communicable Diseases
Candidiasis, Oral
RNA Virus Infections
Sexually Transmitted Diseases, Viral
Slow Virus Diseases
Immune System Diseases
Candidiasis
Acquired Immunodeficiency Syndrome

Infection
Immunologic Deficiency Syndromes
Virus Diseases
Mycoses
HIV Infections
Sexually Transmitted Diseases
Lentivirus Infections
Stomatognathic Diseases
Retroviridae Infections

ClinicalTrials.gov processed this record on May 07, 2009