Study of the Regulation of Parathyroid Hormone Secretion in Pseudohypoparathyroidism

This study has been completed.

First Received: February 24, 2000 Last Updated: June 23, 2005 History of Changes

Sponsors and Collaborators:	National Center for Research Resources (NCRR) University of California, Los Angeles
Information provided by:	Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:	NCT00004661

Purpose

OBJECTIVES:

Determine the relationship between serum calcium concentrations and parathyroid hormone secretion in patients with pseudohypoparathyroidism.

Condition
Pseudohypoparathyroidism

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment:	20
Study Start Date:	May 1993

Detailed Description:

PROTOCOL OUTLINE:

Patients are tested for parathyroid hormone response following sequential graded intravenous infusions of sodium citrate and calcium gluconate. Assays include ionized calcium and intact parathyroid hormone.

Eligibility

Ages Eligible for Study:	12 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Pseudohypoparathyroidism, i.e.: Renal resistance to parathyroid hormone OR Albright hereditary osteodystrophy No other illness unless related to pseudohypoparathyroidism No pregnant women

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004661

Sponsors and Collaborators

National Center for Research Resources (NCRR)

University of California, Los Angeles

Investigators

Study Chair:

Mitchell E. Geffner

University of California, Los Angeles

More Information

No publications provided

Study ID Numbers:	199/11909, UCLA-541
Study First Received:	February 24, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00004661 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by Office of Rare Diseases (ORD):

endocrine disorders
pseudohypoparathyroidism
rare disease

Study placed in the following topic categories:

Metabolic Diseases
Rare Diseases
Endocrine System Diseases
Bone Diseases, Metabolic
Albright's Hereditary Osteodystrophy
Bone Diseases
Hormones

Metabolism, Inborn Errors
Pseudohypoparathyroidism
Musculoskeletal Diseases
Genetic Diseases, Inborn
Endocrinopathy
Metabolic Disorder

Additional relevant MeSH terms:

Calcium Metabolism Disorders
Metabolism, Inborn Errors
Pseudohypoparathyroidism
Metabolic Diseases
Genetic Diseases, Inborn

Musculoskeletal Diseases
Bone Diseases, Metabolic
Metal Metabolism, Inborn Errors
Bone Diseases

ClinicalTrials.gov processed this record on May 07, 2009