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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00004574 |
This study will determine whether short term intravenous infusion of vitamins A and E in patients with abetalipoproteinemia can reverse disease symptoms in these patients. Abetalipoproteinemia is an inherited metabolic defect that prevents fat-soluble vitamins, such as A and E, from being absorbed from the intestines into the bloodstream and from being secreted by the liver. The deficiencies of vitamins A and E can result in severe vision impairment and a gait disorder. Treatment with megadoses of these vitamins, taken by mouth, may delay or arrest symptoms, but many continue to progress.
For this study, a single patient with moderately severe eye and neurological defects will be given essential fatty acids and fat soluble vitamins directly through a vein (intravenously) using FDA-approved replacements with a fat emulsion and multivitamins containing fat-soluble vitamins. This route of administration will bypass the digestive tract, where the absorption problem occurs. The infusions will be given twice a week for one month and then weekly for another month. Blood tests will be done weekly to measure blood lipids (fatty acids and other substances), cell counts, and vitamin levels. Eye and neurological examinations will be done once a month.
Condition |
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Abetalipoproteinemia |
Study Type: | Observational |
Official Title: | Vitamin Replacement in Abetalipoproteinemia |
Estimated Enrollment: | 1 |
Study Start Date: | February 2000 |
Estimated Study Completion Date: | May 2001 |
Fat-soluble vitamins are normally absorbed from the diet through the gastrointestinal tract and incorporated into fat-rich particles called chylomicrons made in the intestinal wall. Chylomicrons are secreted by the intestine into the bloodstream. In a rare lipid metabolic disorder called abetalipoproteinemia, a defect in the assembly of the fat and vitamin containing particles prevents the formation of chylomicrons resulting in the malabsorption of fat and fat-soluble vitamins. A similar assembly defect of fat and fat-soluble vitamins occurs in the liver and prevents the secretion of these particles. Severe fat-soluble vitamin deficiency results even despite mega doses of oral fat-soluble vitamins. Clinically, the subjects develop neurologic and ophthalmologic symptoms similar to those in Vitamin A and E deficiency. This study is designed to determine whether short-term intravenous fat-soluble vitamins and fat emulsion can reverse the neurologic and ophthalmologic complications of fat-soluble vitamin deficiency based on noninvasive procedures routinely employed in clinical practice.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
None provided - protocol is intended for one patient only.
Study ID Numbers: | 000076, 00-H-0076 |
Study First Received: | February 17, 2000 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00004574 History of Changes |
Health Authority: | United States: Federal Government |
Abetalipoproteinemia Ataxia Retinitis Pigmentosa Vitamin A Vitamin E |
Lipid Metabolism, Inborn Errors Retinitis Hypolipoproteinemias Hypolipoproteinemia Abetalipoproteinemia Hypobetalipoproteinemias Pigmentary Retinopathy Tocopherols Metabolism, Inborn Errors Acanthocytosis Retinol palmitate Vitamins Retinitis Pigmentosa Ataxia |
Tocotrienols Micronutrients Metabolic Disorder Dyslipidemias Tocopherol acetate Metabolic Diseases Trace Elements Alpha-Tocopherol Cone Rod Dystrophy Vitamin E Genetic Diseases, Inborn Vitamin A Lipid Metabolism Disorders |
Lipid Metabolism, Inborn Errors Metabolic Diseases Growth Substances Physiological Effects of Drugs Hypolipoproteinemias Pharmacologic Actions Abetalipoproteinemia |
Hypobetalipoproteinemias Metabolism, Inborn Errors Genetic Diseases, Inborn Vitamins Micronutrients Dyslipidemias Lipid Metabolism Disorders |