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Sponsored by: |
National Institute on Deafness and Other Communication Disorders (NIDCD) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00004570 |
Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing-the way the brain analyzes the timing and patterns of sounds-are an inherited trait.
Families with auditory temporal processing deficits are sought in order to identify the genes responsible for auditory temporal processing deficits.
Children and adults with a diagnosis or history of language impairment in the family and their family members-both affected and non-affected-are eligible for this two-part study. In Part 1, participants undergo a series of language tests and listening tests to measure various characteristics of how they perceive sound. In Part 2, they are interviewed about language disorders, learning disabilities, and other medical problems of family members. This information is used to construct a pedigree (family tree diagram) showing the pattern of inheritance of family traits. Study subjects whose pedigree indicates that language disorders may be hereditary in their family will provide either a small blood sample (1 to 2 tablespoons) or a tissue specimen obtained from a cheek swab (rubbing the inside of the cheek with a small brush or cotton swabs). The sample will be used to isolate DNA for genetic analysis.
Condition |
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Auditory Perceptual Disorder Language Delay Language Disorder |
Study Type: | Observational |
Official Title: | Identification of Hereditary Auditory Temporal Processing Deficits |
Estimated Enrollment: | 800 |
Study Start Date: | February 2000 |
Recent research implicates auditory processing deficits in the etiology of language impairments, but no standard methodology has been employed to determine whether auditory processing deficits are heritable traits. We are presently evaluating a battery of auditory processing measures in twins recruited from the general population. Our data indicates that performance on some of these tests has a significantly heritable component. We seek IRB approval to recruit these research subjects and their families into genetic studies to investigate the heritability of auditory temporal processing characteristics, and identify the causative genes.
Ages Eligible for Study: | 12 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Diagnosis of auditory processing disorder (APD/CAPD) based on two or more standardized tests of auditory processing.
Age 12 to 85.
EXCLUSION CRITERIA:
Hearing loss with onset prior to age 20 years, defined as:
History of chronic/recurrent otitis media
History of ear surgery
History or diagnosis of central nervous system lesions/pathology, including:
Currently on medications capable of altering CNS function
History of treatment with ototoxic medication
History or diagnosis of:
Non-English Speaking
English as a second language
Diagnosis of auditory neuropathy
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institute on Deafness and Other Communication Disorders (NIDCD), 9000 R | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 000073, 00-DC-0073 |
Study First Received: | February 14, 2000 |
Last Updated: | April 14, 2009 |
ClinicalTrials.gov Identifier: | NCT00004570 History of Changes |
Health Authority: | United States: Federal Government |
Temporal Processing Language Impairment Linkage Analysis Inheritance Language Delay |
Healthy Auditory Temporal Processing Disorder Language Impairment Speech Impediment |
Otorhinolaryngologic Diseases Retrocochlear Diseases Auditory Perceptual Disorder Language Development Disorders Language Disorders Central Nervous System Diseases Healthy Brain Diseases Ear Diseases Cognition Disorders Auditory Diseases, Central |
Signs and Symptoms Delirium, Dementia, Amnestic, Cognitive Disorders Auditory Perceptual Disorders Mental Disorders Neurologic Manifestations Dementia Neurobehavioral Manifestations Perceptual Disorders Communication Disorders Delirium |
Disease Otorhinolaryngologic Diseases Retrocochlear Diseases Nervous System Diseases Language Development Disorders Language Disorders Central Nervous System Diseases Brain Diseases Ear Diseases Cognition Disorders |
Auditory Diseases, Central Signs and Symptoms Pathologic Processes Delirium, Dementia, Amnestic, Cognitive Disorders Auditory Perceptual Disorders Mental Disorders Neurologic Manifestations Neurobehavioral Manifestations Perceptual Disorders Communication Disorders |