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Sponsored by: |
House Ear Institute |
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Information provided by: | Office of Rare Diseases (ORD) |
ClinicalTrials.gov Identifier: | NCT00004483 |
OBJECTIVES:
I. Define the growth rates and clinical course of NF2-related tumors in patients with neurofibromatosis type 2. Associate growth rate with physical function.
Condition |
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Schwannoma, Vestibular Neurofibromatosis 2 Meningioma |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal |
Estimated Enrollment: | 100 |
Study Start Date: | January 2002 |
PROTOCOL OUTLINE: Data on the clinical course and growth rate of NF2-related tumors in patients with neurofibromatosis 2. Patients are evaluated each year on a cranial and a spinal MRI, eye tests, hearing tests, quality of life, neurological tests, and physical functioning.
Ages Eligible for Study: | 5 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
Bilateral vestibular schwannoma OR Family history of neurofibromatosis 2 (first degree family relative) AND Unilateral vestibular schwannoma at under 30 years OR Any 2 of the following: Meningioma Glioma Schwannoma Juvenile posterior subcapsular lenticular opacity/juvenile cortical cataract
--Prior/Concurrent Therapy--
--Patient Characteristics--
United States, California | |
House Ear Institute | |
Los Angeles, California, United States, 90057-9927 |
Study Chair: | William H. Slattery, III | House Ear Institute |
Study ID Numbers: | 199/14226, HEI-NF2, HEI-DAMD17-01-1-0710 |
Study First Received: | October 18, 1999 |
Last Updated: | September 27, 2005 |
ClinicalTrials.gov Identifier: | NCT00004483 History of Changes |
Health Authority: | Unspecified |
Meningeal Neoplasms Vestibulocochlear Nerve Diseases Otorhinolaryngologic Neoplasms Neuroma, Acoustic Retrocochlear Diseases Central Nervous System Neoplasms Neurodegenerative Diseases Ear Diseases Neurofibromatosis 1 Neurofibromatosis 2 Heredodegenerative Disorders, Nervous System Neurofibromatosis Type 1 Neuromuscular Diseases Neurofibroma Neurofibromatosis Type 2 |
Neoplasms, Germ Cell and Embryonal Neuroepithelioma Meningioma Nervous System Neoplasms Neurocutaneous Syndromes Otorhinolaryngologic Diseases Neurilemmoma Neuroendocrine Tumors Neuroectodermal Tumors Neoplastic Syndromes, Hereditary Genetic Diseases, Inborn Peripheral Nervous System Diseases Neurofibromatoses Peripheral Nervous System Neoplasms Neuroma |
Vestibulocochlear Nerve Diseases Meningeal Neoplasms Otorhinolaryngologic Neoplasms Neuroma, Acoustic Retrocochlear Diseases Neoplasms, Nerve Tissue Cranial Nerve Neoplasms Central Nervous System Neoplasms Neurodegenerative Diseases Ear Diseases Neurofibromatosis 1 Neurofibromatosis 2 Heredodegenerative Disorders, Nervous System Neoplasms by Site Neuromuscular Diseases |
Neurofibroma Neoplasms, Germ Cell and Embryonal Neoplasms, Vascular Tissue Meningioma Nervous System Neoplasms Neurocutaneous Syndromes Otorhinolaryngologic Diseases Neoplasms by Histologic Type Nervous System Diseases Neurilemmoma Neuroendocrine Tumors Neuroectodermal Tumors Neoplasms Neoplastic Syndromes, Hereditary Genetic Diseases, Inborn |