Genetic Linkage Study for Hereditary Pancreatitis

This study is currently recruiting participants.

Verified by Office of Rare Diseases (ORD), September 2006

First Received: October 18, 1999 Last Updated: September 5, 2006 History of Changes

Sponsors and Collaborators:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) University of Pittsburgh
Information provided by:	Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:	NCT00004475

Purpose

OBJECTIVES:

I. Establish linkage in families with hereditary pancreatitis between the phenotype and a chromosomal locus (loci) that contains the responsible gene.

Condition	Intervention
Pancreatitis	Procedure: genetic testing

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History

Further study details as provided by Office of Rare Diseases (ORD):

Study Start Date:

December 1998

Detailed Description:

PROTOCOL OUTLINE: This is a genetics study. Blood samples are collected from patients and family members. DNA is extracted from the blood and used for genotypic analysis and linkage analysis. Patients do not necessarily receive the results of the genetic testing and the results do not influence the type or duration of treatment.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Diagnosis of hereditary pancreatitis with confirmation of phenotype by: Onset of pain before age 20 Amylase elevation at least 2 times normal Surgical or postmortem confirmation of pancreatitis Unequivocal evidence of pancreatic exocrine insufficiency in the absence of trauma, alcohol abuse, elevated serum lipids, or other known causes
Family member of a patient diagnosed with hereditary pancreatitis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004475

Locations

United States, Pennsylvania
University of Pittsburgh, Presbyterian University Hospital	Recruiting
Pittsburgh, Pennsylvania, United States, 15213-2582
Contact: David C. Whitcomb 412-648-9115
Contact: Beth D. Elinoff 888-748-8362 elinoffb@msx.dept-med.pitt.edu

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

University of Pittsburgh

Investigators

Study Chair:

David C. Whitcomb

University of Pittsburgh

More Information

No publications provided

Study ID Numbers:	199/14042, UPMC-951061, UPMC-R01DK54709-01, UPMC-R03DK51954
Study First Received:	October 18, 1999
Last Updated:	September 5, 2006
ClinicalTrials.gov Identifier:	NCT00004475 History of Changes
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Digestive System Diseases
Hereditary Pancreatitis
Pancreatic Diseases
Pancreatitis
Pancreatitis, Chronic

Additional relevant MeSH terms:

Digestive System Diseases
Pancreatic Diseases
Pancreatitis

ClinicalTrials.gov processed this record on May 07, 2009