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Sponsors and Collaborators: |
National Center for Research Resources (NCRR) Northwestern University |
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Information provided by: | Office of Rare Diseases (ORD) |
ClinicalTrials.gov Identifier: | NCT00004365 |
OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan. II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.
Condition |
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Growth Hormone Deficiency |
Study Type: | Observational |
Study Design: | Screening |
Estimated Enrollment: | 4 |
Study Start Date: | September 1995 |
Estimated Study Completion Date: | February 2000 |
PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated.
All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.
Ages Eligible for Study: | 10 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Study ID Numbers: | 199/11940, NU-571 |
Study First Received: | October 18, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00004365 History of Changes |
Health Authority: | United States: Federal Government |
endocrine disorders growth hormone deficiency rare disease |
Dwarfism Bone Diseases, Endocrine Hypothalamic Diseases Hypopituitary Dwarfism Pituitary Diseases Rare Diseases Endocrine System Diseases Central Nervous System Diseases Dwarfism, Pituitary |
Brain Diseases Hormones Bone Diseases Growth Hormone Deficiency Musculoskeletal Diseases Hypopituitarism Bone Diseases, Developmental Endocrinopathy |
Dwarfism Bone Diseases, Endocrine Hypothalamic Diseases Pituitary Diseases Nervous System Diseases Endocrine System Diseases Central Nervous System Diseases |
Dwarfism, Pituitary Brain Diseases Bone Diseases Musculoskeletal Diseases Hypopituitarism Bone Diseases, Developmental |