Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

This study has been completed.

First Received: October 18, 1999 Last Updated: June 23, 2005 History of Changes

Sponsors and Collaborators:	National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Ohio State University
Information provided by:	National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:	NCT00004305

Purpose

OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N).

II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.

Condition
IGA Glomerulonephritis

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening

Further study details as provided by National Center for Research Resources (NCRR):

Estimated Enrollment:	105
Study Start Date:	January 1998

Detailed Description:

PROTOCOL OUTLINE:

Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

- IgA glomerulonephritis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004305

Locations

United States, Ohio
Ohio State University
Columbus, Ohio, United States

Sponsors and Collaborators

National Center for Research Resources (NCRR)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Ohio State University

Investigators

Study Chair:

Lee A. Hebert

Ohio State University

More Information

No publications provided

Study ID Numbers:	199/11791, OSU-94H0338
Study First Received:	October 18, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00004305 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):

IgA glomerulonephritis
rare disease
renal and genitourinary disorders

Study placed in the following topic categories:

Glomerulonephritis
Autoimmune Diseases
Urologic Diseases
Nephritis
Rare Diseases

Glomerulonephritis, IGA
Kidney Diseases
Congenital Abnormalities
Berger Disease

Additional relevant MeSH terms:

Glomerulonephritis
Autoimmune Diseases
Immune System Diseases
Urologic Diseases

Nephritis
Glomerulonephritis, IGA
Kidney Diseases

ClinicalTrials.gov processed this record on May 07, 2009