Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
National Cancer Institute (NCI) |
---|---|
Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00491335 |
Background:
The incidence of lung cancer is quite high among people with the human immunodeficiency (HIV) virus. Frequent smoking may explain that cancer increase, given that 50% to 70% of HIV-infected people are current smokers.
Recent research suggests that other factors may be involved as well. Smoking habits, such as smoking earlier in life or smoking more cigarettes a day than others do, may have a role. Also, HIV-infected smokers seem to have a greater risk of chronic obstructive pulmonary disease (COPD). The association of HIV and COPD is important, because COPD itself is linked to an increased risk of lung cancer.
About 1,600 subjects from the study known as ALIVE (AIDS Linked to the Intra-Venous Experience), which began in 1988 in Baltimore, Maryland, will be given a detailed questionnaire on smoking behaviors and lung cancer risk factors. They will also have spirometry testing, to evaluate lung function.
Objectives:
To better characterize smoking habits and compare tobacco use among HIV-infected and uninfected drug users.
To compare serum cotinine levels and spirometry results, as a marker of tobacco use and a marker of damage to lung function, respectively.
Eligibility:
Patients 18 years of age and older who are in the ALIVE cohort.
Design:
Patients undergo the following procedures:
Condition |
---|
HIV Infections AIDS Lung Cancer Tobacco Addiction Drug Addiction |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | HIV Infection and Tobacco Use Among Injection Drug Users in Baltimore, MD: A Pilot Study of Biomarkers |
Estimated Enrollment: | 1600 |
Study Start Date: | June 2007 |
Lung cancer incidence is substantially elevated among people infected with human immunodeficiency virus (HIV). Although frequent smoking may partly explain this increase, recent work suggests other factors may also be involved. To better characterize smoking habits and lung cancer risk in HIV-infected people, the investigators propose a cross-sectional pilot study of HIV-infected and uninfected injection drug users in the ALIVE cohort in Baltimore, Maryland. A detailed questionnaire on smoking behaviors and other lung cancer risk factors will be administered to all ~ 1600 cohort subjects. In addition, the investigators will measure serum cotinine (a marker of recent smoking intensity) for a sample of 340 African American males from the cohort, stratified on the amount of cigarette use, HIV status, and CD4 count. Spirometry will be performed on the entire group of 1600 subjects, to assess for chronic obstructive pulmonary disease. Differences between HIV-infected and uninfected subjects in smoking habits, exposure to tobacco, or lung damage will identify areas for future investigation.
Ages Eligible for Study: | 17 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Must be a participant in the ALIVE Study
EXCLUSION CRITERIA:
Not a participant in the ALIVE Study
Contact: Eric A. Engels, M.D. | (301) 435-4722 | engelse@exchange.nih.gov |
United States, Maryland | |
Johns Hopkins University | Recruiting |
Baltimore, Maryland, United States, 21205 |
Study ID Numbers: | 999907173, 07-C-N173 |
Study First Received: | June 23, 2007 |
Last Updated: | March 25, 2009 |
ClinicalTrials.gov Identifier: | NCT00491335 History of Changes |
Health Authority: | United States: Federal Government |
AIDS Lung Cancer Emphysema Nicotine |
HIV Infection Lung Cancer Smoking |
Nicotine polacrilex Thoracic Neoplasms Emphysema Behavior, Addictive Sexually Transmitted Diseases, Viral Acquired Immunodeficiency Syndrome Disorders of Environmental Origin Impulsive Behavior Immunologic Deficiency Syndromes Pulmonary Emphysema Virus Diseases |
Compulsive Behavior Smoking Respiratory Tract Diseases Nicotine Mental Disorders HIV Infections Lung Neoplasms Lung Diseases Sexually Transmitted Diseases Substance-Related Disorders Retroviridae Infections |
Thoracic Neoplasms Communicable Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Disorders of Environmental Origin Infection Compulsive Behavior Neoplasms by Site Respiratory Tract Diseases Mental Disorders Lung Neoplasms Substance-Related Disorders Retroviridae Infections |
Respiratory Tract Neoplasms RNA Virus Infections Behavior, Addictive Immune System Diseases Acquired Immunodeficiency Syndrome Impulsive Behavior Immunologic Deficiency Syndromes Virus Diseases Neoplasms HIV Infections Lung Diseases Sexually Transmitted Diseases Lentivirus Infections |