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Sponsors and Collaborators: |
University of Michigan Centers for Disease Control and Prevention |
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Information provided by: | University of Michigan |
ClinicalTrials.gov Identifier: | NCT00490633 |
Pharmaceutical interventions, particularly vaccination, have been the principal public health method of preventing and controlling seasonal influenza.
Other less invasive non-pharmaceutical interventions include the use of face masks and hand hygiene. In Asia, masks are used extensively, especially in Japan, but with only circumstantial evidence of efficacy. Although there are numerous studies that support hand hygiene as an effective measure for decreasing transmission of enteric infections, there are fewer data assessing the effect of hand hygiene on respiratory illnesses. Therefore it is proposed that a study be conducted on the use of face masks with and without the use of hand hygiene in comparison to no intervention in residence housing units of the University of Michigan. The interventions will be carried out during a period of influenza transmission that is defined by surveillance conducted at the University Health Service. Data will be collected on use of the interventions and the occurrence of influenza and other illnesses. When illness occurs meeting a case definition, specimens for viral isolation will be collected in all intervention settings. Face masks could theoretically lead to a large reduction in transmission frequency of influenza, especially if most transmission occurs by the airborne (large or small droplet) route. Even a modest reduction could have a major effect during an influenza pandemic.
Condition | Intervention |
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Influenza |
Behavioral: Ear Loop Procedure Mask Behavioral: 62% Ethyl Alcohol Hand Sanitizer |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Single Blind, Uncontrolled, Factorial Assignment, Efficacy Study |
Official Title: | Reducing the Transmission of Influenza by Face Masks |
Enrollment: | 1420 |
Study Start Date: | October 2006 |
Estimated Study Completion Date: | April 2008 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Michigan | |
University of Michigan | |
Ann Arbor, Michigan, United States, 48104 |
Principal Investigator: | Arnold S Monto, MD | University of Michigan |
Principal Investigator: | Allison E Aiello, PhD | University of Michigan |
Study ID Numbers: | HUM00008566 |
Study First Received: | June 21, 2007 |
Last Updated: | June 22, 2007 |
ClinicalTrials.gov Identifier: | NCT00490633 History of Changes |
Health Authority: | United States: Institutional Review Board; United States: Federal Government |
Influenza Non Pharmaceutical Intervention Face Mask Hand Hygiene |
Virus Diseases Anti-Infective Agents, Local Respiratory Tract Diseases Respiratory Tract Infections Facies |
Influenza, Human Central Nervous System Depressants Orthomyxoviridae Infections Ethanol |
Anti-Infective Agents RNA Virus Infections Physiological Effects of Drugs Central Nervous System Depressants Orthomyxoviridae Infections Pharmacologic Actions Virus Diseases |
Anti-Infective Agents, Local Respiratory Tract Infections Respiratory Tract Diseases Therapeutic Uses Influenza, Human Central Nervous System Agents Ethanol |