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Periodontal and Periapical Inflammation and Pregnancy
This study is ongoing, but not recruiting participants.
First Received: June 20, 2007   Last Updated: January 7, 2008   History of Changes
Sponsored by: University of Mississippi Medical Center
Information provided by: University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT00490165
  Purpose

This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.


Condition
Periodontal Disease
Periapical Disease
Pregnancy
Diabetes
Cardiovascular Disease
Dental Caries

MedlinePlus related topics: Diabetes
U.S. FDA Resources
Study Type: Observational
Study Design: Retrospective
Official Title: Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes

Further study details as provided by University of Mississippi Medical Center:

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment: 500
Study Start Date: March 2007
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   10 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.

Criteria

Inclusion Criteria:

  • Female
  • Child bearing age or above

Exclusion Criteria:

  • Male
  • Very young children (before child-bearing age)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00490165

Locations
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39202
Sponsors and Collaborators
University of Mississippi Medical Center
Investigators
Principal Investigator: Jennifer L Bain, BS University of Mississippi Medical Center
Study Director: Roger Johnson, PhD; DMD University of Mississippi Medical Center
  More Information

No publications provided

Responsible Party: University of Mississippi Medical Center ( Roger Johnson/Study Sponsor/Professor )
Study ID Numbers: 2006-0198
Study First Received: June 20, 2007
Last Updated: January 7, 2008
ClinicalTrials.gov Identifier: NCT00490165     History of Changes
Health Authority: United States: Institutional Review Board

Study placed in the following topic categories:
Mouth Diseases
Tooth Diseases
Periodontal Diseases
Periapical Diseases
Diabetes Mellitus
Stomatognathic Diseases
Dental Caries
Inflammation

Additional relevant MeSH terms:
Mouth Diseases
Tooth Diseases
Periodontal Diseases
Pathologic Processes
Periapical Diseases
Jaw Diseases
Cardiovascular Diseases
Stomatognathic Diseases
Tooth Demineralization
Dental Caries
Inflammation

ClinicalTrials.gov processed this record on May 07, 2009