Assessment of Pulmonary Involvement inUlcerative Colitis by Induced Sputum - Full Text View

Sponsored by:	Hillel Yaffe Medical Center
Information provided by:	Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier:	NCT00490048

Purpose

Ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A Fireman E: Assessment of pulmonary involvement in Crohn’s disease by induced sputum. Am J Gastroenterol 2000;95(30):730-734. )

Condition	Intervention
Ulcerative Colitis	Procedure: Induced sputum (inhalation of 3.5% saline)

Genetics Home Reference related topics: Crohn disease

MedlinePlus related topics: Ulcerative Colitis

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Screening, Open Label, Uncontrolled, Single Group Assignment, Safety Study

Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:

lung involvment in Ulcerative colitis patients

Estimated Enrollment:	20
Study Start Date:	June 2007
Study Completion Date:	June 2007

Detailed Description:

Twenty Ulcerative colitis patients and 20 control subjects (all nonsmokers) without respiratory symptoms will be tested. The induce sputum by 20' inhalation of 3.5% saline using ultrasonic nebulizer. Samples will studied by differential counts of 200 cells on cytopreps stained by Giemsa.

T-lymphocyte subset analyses were done by FACS using three monoclonal antibodies: CD3 = total T cells, CD4 = T helper cells, and CD8 = T suppressor-cytotoxic cells. CD4/CD8 >2.5 was considered abnormal.

Eligibility

Ages Eligible for Study:	18 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

All the ulceratvive colitis patients without lung involvmentage 18-75 years of age

Exclusion Criteria:

Pregnant women
Non cooperative patients
Smoker
Lung disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00490048

Sponsors and Collaborators

Hillel Yaffe Medical Center

Investigators

Principal Investigator:

Zvi Fireman, MD

Hillel- Yaffe Med. Ctr

More Information

Publications:

Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A, Lazarov E, Fireman E. The use of induced sputum in the assessment of pulmonary involvement in Crohn's disease. Am J Gastroenterol. 2000 Mar;95(3):730-4.

Study ID Numbers:	ISUC.CTIL
Study First Received:	June 21, 2007
Last Updated:	June 21, 2007
ClinicalTrials.gov Identifier:	NCT00490048 History of Changes
Health Authority:	Israel: Ministry of Health

Keywords provided by Hillel Yaffe Medical Center:

Ulcerative colits
lung
Induced sputum
Our aim to evaluate lung involvement in Ulcerative colitis patients by induced sputum

Study placed in the following topic categories:

Digestive System Diseases
Gastrointestinal Diseases
Ulcer
Colonic Diseases
Inflammatory Bowel Diseases

Colitis, Ulcerative
Intestinal Diseases
Gastroenteritis
Colitis

Additional relevant MeSH terms:

Pathologic Processes
Digestive System Diseases
Gastrointestinal Diseases
Ulcer
Colonic Diseases

Inflammatory Bowel Diseases
Colitis, Ulcerative
Intestinal Diseases
Gastroenteritis
Colitis

ClinicalTrials.gov processed this record on May 07, 2009