Advanced MRI in Major Depression - Full Text View

Sponsored by:	University of Aarhus
Information provided by:	University of Aarhus
ClinicalTrials.gov Identifier:	NCT00613912

Purpose

Depression is the most common psychiatric disorder.

3-5% of a given population has major depression.
Less than 50% of the depressed in Denmark are diagnosed with major depression.
25-50% of the depressed have a relative with major depression-underlying brain pathology?

The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Condition	Intervention
Depressive Disorder, Major	Other: Magnetic Resonance Imaging

MedlinePlus related topics: Depression MRI Scans

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Prospective
Official Title:	Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression

Further study details as provided by University of Aarhus:

Primary Outcome Measures:

Differences in morphological and functional cerebral MRI findings in patients suffering from major depression [ Time Frame: 6 months from first MRI in each patient ] [ Designated as safety issue: No ]

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	45
Study Start Date:	March 2008
Estimated Study Completion Date:	June 2010
Estimated Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
A Ambulant patients with major depression	Other: Magnetic Resonance Imaging Morphological sequences Arterial Spin Labelling (Perfusion) Diffusion Tensor Imaging 32 directions Scan time 45 min. Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol TE 30 Reference voxel in Parietal white matter Voxel size 2.5cm

Detailed Description:

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or with out SSRI), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, neural connectivity in the brain with Diffusion Tensor Imaging and concentrations of different metabolites with MR spectroscopy will be performed.

MR protocol: T2 sag, T2 FLAIR ax, ASL ax, DTI ax, MRS and FSPGR sag. Scan time 45 min.

Eligibility

Ages Eligible for Study:	20 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Ambulant patients with major depression, selected from the Department of Psychatry, Aalborg hospital-Århus University Hospital.

Criteria

Inclusion Criteria:

Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector.

Exclusion Criteria:

If the patient has pacemaker or other magnetic devices
Pregnancy
Has had an operation in the brain
bipolar disorder

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00613912

Sponsors and Collaborators

University of Aarhus

Investigators

Principal Investigator:

Elna-Marie B Larsson, Professor

Aalborg hospital-a part of Århus University hospital/Aarhus University

More Information

No publications provided

Responsible Party:	UAarhus ( Professor Elna-Marie Larsson )
Study ID Numbers:	AUFF-2005-740-004, E-2007-SUN-1-71, N-20070036
Study First Received:	January 31, 2008
Last Updated:	March 24, 2009
ClinicalTrials.gov Identifier:	NCT00613912 History of Changes
Health Authority:	Denmark: National Board of Health; Denmark: Danish Dataprotection Agency; Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by University of Aarhus:

Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Perfusion,Diffusion Magnetic Resonance Imaging

Study placed in the following topic categories:

Depression
Mental Disorders
Inositol
Mood Disorders

Depressive Disorder, Major
Depressive Disorder
Behavioral Symptoms

Additional relevant MeSH terms:

Depression
Mental Disorders
Mood Disorders

Depressive Disorder, Major
Depressive Disorder
Behavioral Symptoms

ClinicalTrials.gov processed this record on May 07, 2009