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Sponsored by: |
University Health Network, Toronto |
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Information provided by: | University Health Network, Toronto |
ClinicalTrials.gov Identifier: | NCT00188890 |
Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma).
Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.
Condition |
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Lung Cancer Mesothelioma |
Study Type: | Observational |
Study Design: | Case Control |
Official Title: | Early Diagnosis of Mesothelioma and Lung Cancer Following Asbestos Exposure Using Low-Dose Computed Tomography |
Estimated Enrollment: | 1000 |
Study Start Date: | March 2005 |
Estimated Study Completion Date: | March 2010 |
Groups/Cohorts |
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1
prior exposure to asbestos
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Ages Eligible for Study: | 30 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
prior exposure to asbestos and or documented pleural plaques
Inclusion Criteria:
prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)
Resident of Ontario, Canada
Exclusion Criteria:
prior cancer (except non-melanotic skin cancer)
Contact: Demetris Patsios, MD | Tel: (416) 603-5800 ext 2583 | demetris.patsios@uhn.on.ca |
Contact: Brenda O'Sullivan | 416-340-4800 ext 5686 | Brenda.O'Sullivan@uhn.on.ca |
Canada, Ontario | |
Princess Margaret Hospital | Recruiting |
Toronto, Ontario, Canada | |
Contact: Demetris Patsios, MD Tel: (416) 603-5800 ext 2583 demetris.patsios@uhn.on.ca | |
Contact: Brenda O'Sullivan, MD 416-340-4800 ext 5686 brenda.o'sullivan@uhn.on.ca |
Principal Investigator: | Demetris Patsios, MD | University Health Network, Toronto |
Principal Investigator: | Michael Johnston, MD | University Health Network, Toronto |
Study ID Numbers: | Asbestos Screening Study |
Study First Received: | September 12, 2005 |
Last Updated: | October 31, 2007 |
ClinicalTrials.gov Identifier: | NCT00188890 History of Changes |
Health Authority: | Canada: Health Canada |
Lung Cancer Mesothelioma Asbestos Screening Early Diagnosis |
Thoracic Neoplasms Respiratory Tract Diseases Lung Neoplasms Lung Diseases |
Mesothelioma Adenoma Neoplasms, Glandular and Epithelial |
Thoracic Neoplasms Respiratory Tract Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Respiratory Tract Diseases |
Neoplasms, Mesothelial Lung Neoplasms Lung Diseases Mesothelioma Adenoma Neoplasms, Glandular and Epithelial |