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Sponsors and Collaborators: |
University Hospital, Angers Assistance Publique - Hôpitaux de Paris |
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Information provided by: | University Hospital, Angers |
ClinicalTrials.gov Identifier: | NCT00188019 |
Hereditary paraganglioma -due to SDH (SDHD, SDHB, SDHC) germline mutations- causes paragangliomas and pheochromocytomas. Presymptomatic genetic testing should be offered to all first-degree relatives if an SDH mutation is detected in an index case with paraganglioma or pheochromocytoma. The main objective of our national clinical research project is to test different screening methods to detect presymptomatic tumors in order to establish guidelines for the work-up and the follow-up of SDH mutation carriers.
Condition | Intervention |
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Paraganglioma Pheochromocytoma |
Procedure: diagnosis methods |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Historical Control, Single Group Assignment |
Official Title: | Evaluation Des méthodes De dépistage Du Paragangliome héréditaire Chez Les Sujets prédisposés génétiquement |
Ages Eligible for Study: | 6 Years and older |
Genders Eligible for Study: | Both |
Inclusion Criteria: identification of an SDH (SDHD, SDHD, SDHC) germline mutation
Contact: Anne-Paule Gimenez-Roqueplo, MD, PhD | 33 1 56 09 38 81 | anne-paule.gimenez@hop.egp.ap-hop-paris.fr |
France | |
Européen Georges Pompidou Hospital | Recruiting |
Paris, France, 75015 | |
Contact: Anne-Paule Gimenez-Roqueplo, MD, PhD 33 1 56 09 38 78 ext 38 81 anne-paule.gimenez@hop.egp.ap-hop-paris.fr | |
Principal Investigator: Anne-Paule Gimenez-Roqueplo, MD, PhD |
Principal Investigator: | Vincent Rohmer, MD | University Angers Hospital |
Principal Investigator: | Anne-Paule Gimenez-Roqueplo, MD, PhD | Paris-Descartes University, Européen Georges Pompidou Hospital, Assistance Publique des Hôpitaux de Paris |
Study ID Numbers: | PHRC 04-01 |
Study First Received: | September 12, 2005 |
Last Updated: | September 12, 2005 |
ClinicalTrials.gov Identifier: | NCT00188019 History of Changes |
Health Authority: | France: Ministry of Health |
Neuroectodermal Tumors Paraganglioma Neoplasms, Germ Cell and Embryonal |
Neuroepithelioma Pheochromocytoma Neuroendocrine Tumors |
Neuroectodermal Tumors Neoplasms Paraganglioma Neoplasms by Histologic Type |
Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue Pheochromocytoma Neuroendocrine Tumors |