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Detection and Treatment of Depression in Patients Admitted to the General Hospital
This study is currently recruiting participants.
Verified by Radboud University, December 2008
First Received: August 27, 2007   Last Updated: December 24, 2008   History of Changes
Sponsored by: Radboud University
Information provided by: Radboud University
ClinicalTrials.gov Identifier: NCT00521911
  Purpose

Depression is a common disorder among patients with a somatic illness admitted to the general hospital. Patients with depression do worse in terms of their somatic symptoms or functioning that those without depression. They also stay in the hospital for longer.

That is the reason that we are interested to know whether patients with depression do better if their depression is recognised earlier and treated appropriately. We would like to find out which questionnaires are most suitable in clinical practice to help pick up patients with a depression. In addition, we would like to know whether a short-term psychological treatment of depression would be of any help. We hope to be able to show that this treatment would not only result in a reduction of depressive symptoms, but also in a better and quicker recovery of the somatic illness.

The treatment will consist of 6 to 9 weekly sessions of one hour, conducted by a cognitive behavioural assistant. Initially, the treatment will take place in the hospital. When patients are discharged, treatment sessions will continue at home. The treatment will focus on things like recognising and challenging unhelpful thoughts, planning of activities, and testing out of predictions by setting up behavioural experiments. Three monthly booster sessions will be offered to help patients to maintain their gains and prevent relapse. We will reassess the symptoms of the patients at three and six months after the end of treatment.


Condition Intervention Phase
Depressive Disorder
Depression
Behavioral: Cognitive Behavioural Therapy
Phase II

MedlinePlus related topics: Depression
U.S. FDA Resources
Study Type: Interventional
Study Design: Treatment, Randomized, Double Blind (Investigator, Outcomes Assessor), Parallel Assignment, Efficacy Study

Further study details as provided by Radboud University:

Primary Outcome Measures:
  • Depressive Disorder Physical symptoms [ Time Frame: 9 months ]

Secondary Outcome Measures:
  • - Functional impairment (RAND 36) - Cost-effectiveness (TiC-P) - Quality of Life (EQ5D) [ Time Frame: 9 months ]

Estimated Enrollment: 60
Study Start Date: August 2007
Estimated Study Completion Date: December 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
1: Active Comparator
Cognitive Behavioural Therapy
Behavioral: Cognitive Behavioural Therapy
2: No Intervention
Treatment as Usual

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Depressive Disorder

Exclusion Criteria:

  • Severe Physical Disfunction
  • Severe Cognitive Disfunction
  • Speech and/or Hearing Disorder
  • Limited knowledge of the Dutch language
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00521911

Contacts
Contact: Matthijs W. Beltman, MSc +31 (0)24 3668008 mw.beltman@psy.umcn.nl

Locations
Netherlands, Gelderland
Radboud University Nijmegen Medical Centre Recruiting
Nijmegen, Gelderland, Netherlands, 6500 HB
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Anne EM Speckens, PhD, MD Radboud University
  More Information

Additional Information:
No publications provided

Responsible Party: Radboud University Medical Center ( Anne EM Speckens, PhD, MD )
Study ID Numbers: PROJECT9999
Study First Received: August 27, 2007
Last Updated: December 24, 2008
ClinicalTrials.gov Identifier: NCT00521911     History of Changes
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Radboud University:
Intervention Studies
Randomized Controlled Trials
Cognitive Therapy
Hospitals, General
Prevalence

Study placed in the following topic categories:
Depression
Mental Disorders
Mood Disorders
Depressive Disorder
Behavioral Symptoms

Additional relevant MeSH terms:
Depression
Mental Disorders
Mood Disorders
Depressive Disorder
Behavioral Symptoms

ClinicalTrials.gov processed this record on May 07, 2009