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Sponsored by: |
V.K.V. American Hospital, Istanbul |
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Information provided by: | V.K.V. American Hospital, Istanbul |
ClinicalTrials.gov Identifier: | NCT00521443 |
Various morphological abnormalities of human oocytes were reported to detrimentally affect embryo development. We observed development of frozen thawed embryos derived from oocytes with normal or abnormal morphological features to the blastocyst stage. Cytoplasmic abnormalities of the oocytes were found to negatively affect cryosurvival potential of the embryos.
Condition | Intervention |
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Cryopreservation Blastocyst |
Procedure: Cryopreservation, thawing and blastocyst culture |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Groups/Cohorts | Assigned Interventions |
---|---|
Normal: Control
Embryos derived from morphologically normal MII oocytes
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Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Irregular Shapes: Case
Embryos derived from irregularly shaped oocytes.
|
Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Large PVS: Case
Embryos derived from oocytes with large perivitelline space.
|
Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Dark Zona: Case
Embryos derived from oocytes with dark zona pellucida
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Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
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Dark cytoplasm: Case
Embryos derived from oocytes with dark cytoplasm
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Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Vacuolar cytoplasm: Case
Embryos derived from oocytes with vacuolated cytoplasm
|
Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
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Central granulation: Case
Embryos derived from oocytes with centrally granulated cytoplasm
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Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Double extra: Case
Embryos derived from oocytes with double extracytoplasmic abnormalities
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Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
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Double combined: Case
Embryos derived from oocytes with any combination of one extracytoplasmic and one cytoplasmic anomaly
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Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Double cytoplasmic: Case
Embryos derived from oocytes with any two cytoplasmic anomalies
|
Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Triple extra: Case
Embryos derived from oocytes with triple extracytoplasmic anomaly
|
Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Triple combined: Case
Embryos derived from oocytes with triple combined anomalies
|
Procedure: Cryopreservation, thawing and blastocyst culture
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
|
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Female |
Inclusion Criteria:
Exclusion Criteria:
Turkey | |
VKV American Hospital | |
Istanbul, Turkey, 34365 |
Study Director: | Basak Balaban, B.Sc. | Assisted Reproduction Unit of the VKV American Hospital of Istanbul |
Study ID Numbers: | AH-05/04 |
Study First Received: | August 24, 2007 |
Last Updated: | August 24, 2007 |
ClinicalTrials.gov Identifier: | NCT00521443 History of Changes |
Health Authority: | Turkey: Ministry of Health |