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Sponsored by: |
Kaohsiung Medical University Chung-Ho Memorial Hospital |
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Information provided by: | Kaohsiung Medical University Chung-Ho Memorial Hospital |
ClinicalTrials.gov Identifier: | NCT00834028 |
This project will include at least 40 patients with hepatocellular carcinoma (HCC) who will receive transcatheter arterial chemoembolization (TACE) as a sole method for the management. The serum is collected before and at the 3rd and 7th day after TACE. The serum levels of vascular endothelial growth factor, angiopoietin 2, endostatin and cathepsin L are determined. All patients will be evaluated according to the TNM system for the cancer staging before and 3 months after each session of treatment. The vascularity of tumor, the drug and the dose used for embolization, and the area of infarction will be recorded. These data will be compared with the clinical courses of the patients to obtain the most suitable way in the management of these patients.
Condition |
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Hepatocellular Carcinoma |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Recurrence and Distant Metastases in Hepatocellular Carcinoma Treated by Transcatheter Arterial Chemoembolization : The Roles of VEGF, Cathepsin L, Endostatin, and Angiopoietin-2. |
serum
Enrollment: | 60 |
Study Start Date: | February 2007 |
Study Completion Date: | December 2008 |
Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
patients with hepatocellular carcinoma receive transcatheter arterial chemoembolization
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Transcatheter arterial chemoembolization (TACE) is the traditional method for the palliative management of patients with hepatocellular carcinoma (HCC).
This method will cause tissue hypoxia in area of embolization. Several proangiogenic factors will be induced by the condition of hypoxia. This may have the possibility to promote the proliferation of the residual cancer cells. However, there is no study to clarify this issue. This project will determine the serial changes of serum proangiogenic factors (vascular endothelial growth factor, angiopoietin 2), antiangiogenic factor (endostatin) and cathepsin L before and after TACE. These data will be compared with the clinical courses of the patients to obtain the most suitable way in the management of these patients. This project will include at least 40 patients with HCC who will receive TACE as a sole method for the management. The serum is collected before and at the 3rd and 7th day after TACE. The serum levels of vascular endothelial growth factor, angiopoietin 2, endostatin and cathepsin L are determined. All patients will be evaluated according to the TNM system for the cancer staging before and 3 months after each session of treatment. The vascularity of tumor, the drug and the dose used for embolization, and the area of infarction will be recorded.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
patients with hepatocellular carcinoma
Inclusion Criteria:
Exclusion Criteria:
Taiwan | |
Kaohsiung Medical University Hospital | |
Kaohsiung, Taiwan, 807 |
Principal Investigator: | zu y lin | Kaohsiung Medical University |
Responsible Party: | Kaohsiung Medical University Hospital ( Zu-Yau Lin/Kaohsiung Medical University Hospital ) |
Study ID Numbers: | KMUH-IRB-950168 |
Study First Received: | February 1, 2009 |
Last Updated: | February 1, 2009 |
ClinicalTrials.gov Identifier: | NCT00834028 History of Changes |
Health Authority: | Taiwan: Department of Health |
hepatocellular carcinoma vascular endothelial growth factor angiopoietin cathepsin |
Liver Diseases Digestive System Neoplasms Carcinoma, Hepatocellular Endostatins Endothelial Growth Factors Recurrence Carcinoma Liver Neoplasms |
Digestive System Diseases Neoplasm Metastasis Mitogens Gastrointestinal Neoplasms Adenocarcinoma Hepatocellular Carcinoma Neoplasms, Glandular and Epithelial |
Liver Diseases Neoplasms by Histologic Type Digestive System Neoplasms Carcinoma, Hepatocellular Carcinoma Liver Neoplasms Neoplasms |
Neoplastic Processes Pathologic Processes Neoplasms by Site Digestive System Diseases Neoplasm Metastasis Adenocarcinoma Neoplasms, Glandular and Epithelial |