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Sponsored by: |
University Hospital, Tours |
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Information provided by: | University Hospital, Tours |
ClinicalTrials.gov Identifier: | NCT00479518 |
Patients with stroke or transient ischemic attack (TIA) are at high risk of poor outcome, recurrence of cardiovascular events or vascular death.Until now, no reliable predictive biological marker could be identified in the acute phase of stroke.We hypothese that, in the acute phase of ischemic stroke or TIA, the increase of cardiac ( brain natriuretic peptide, BNP) or renal markers (albuminuria, cystatin C)might predict recurrence of cardiovascular events or vascular death. We want to assess which one of these markers has the best prognosis value , in a prospective study of 300 stroke patients followed during 3 years.
Condition |
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Ischemic Stroke Transient Ischemic Attack |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Prognostic Value of Cardiac and Renal Markers in the Acute Phase of Ischemic Stroke or Transient Ischemic Attack :Albuminuria-Brain Natriuretic Peptide-Cystatine C in Stroke |
Blood Urine
Estimated Enrollment: | 300 |
Study Start Date: | March 2007 |
Estimated Study Completion Date: | March 2012 |
Patients with ischemic stroke or TIA will be included in the 48 hours following the onset of symptoms, in 3 university hospitals.For each patient will be collected
After adjustment on the main clinical prognosis factors, we want to determine wich one of these markers has the best prognosis significance and allows to identify in the acute phase the "high-risk" patients, in order to intensify individual treatment and secondary prevention.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patient with Ischemic stroke or TIA
Inclusion Criteria:
Exclusion Criteria:
Contact: BONNAUD Isabelle, MD | (33) 2 47 47 16 07 | i.bonnaud@chu-tours.fr |
Contact: RAMEAU Pascaline, CRA | (33) 2 47 36 62 49 | rameau@med.univ-tours.fr |
France | |
Service de Neurologie / CHRU de Tours | Recruiting |
TOURS, France, 37044 | |
Contact: BONNAUD Isabelle, MD (33) 2 47 47 16 07 i.bonnaud@chu-tours.fr | |
Contact: RAMEAU Pascaline, CRA (33) 2 47 36 62 49 rameau@med.univ-tours.fr | |
Sub-Investigator: AUTRET Alain, PHD | |
Sub-Investigator: DEBIAIS Séverine, MD | |
Sub-Investigator: SAUDEAU Denis, MD | |
Sub-Investigator: HALIMI Jean-Michel, PHD | |
Service de neurologie / CHU Pontchaillou | Not yet recruiting |
RENNES, France, 35033 | |
Contact: RONZIERE Thomas, MD | |
Sub-Investigator: RONZIERE Thomas, MD | |
Sub-Investigator: PINEL Jean-François, MD | |
Sub-Investigator: CAHAGNE Vincent, MD | |
Service de Neurologie / Hopital LAENNEC | Recruiting |
Nantes, France, 44093 | |
Contact: GUILLON Benoît, MD | |
Sub-Investigator: MAGNE Christine, MD | |
Sub-Investigator: GUILLON Benoît, MD | |
Sub-Investigator: LAPLAUD David, MD | |
Sub-Investigator: WIERTLEWSKI Sandrine, MD |
Principal Investigator: | BONNAUD Isabelle, MD | Service de Neurologie / CHRU de Tours |
Responsible Party: | University Hospital Tours ( University Hospital Tours / Jocelyne Marlière ) |
Study ID Numbers: | PHRI06-IB Cohorte ABC-AVC |
Study First Received: | May 25, 2007 |
Last Updated: | April 9, 2009 |
ClinicalTrials.gov Identifier: | NCT00479518 History of Changes |
Health Authority: | France: Ministry of Health |
stroke transient ischemic attack albuminuria BNP Cystatin C |
Natriuretic Peptide, Brain Ischemic Attack, Transient Albuminuria Cerebral Infarction Stroke Vascular Diseases Central Nervous System Diseases |
Ischemia Brain Diseases Cerebrovascular Disorders Brain Ischemia Brain Infarction Cystatins Infarction |
Ischemic Attack, Transient Cerebral Infarction Stroke Nervous System Diseases Vascular Diseases Central Nervous System Diseases Ischemia |
Brain Diseases Cerebrovascular Disorders Pathologic Processes Brain Ischemia Cardiovascular Diseases Brain Infarction |