Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsors and Collaborators: |
Vanderbilt University National Institutes of Health (NIH) |
---|---|
Information provided by: | Vanderbilt University |
ClinicalTrials.gov Identifier: | NCT00478894 |
In this study we will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.
Condition |
---|
Anterior Cruciate Ligament Osteoarthritis |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ALCR): Onsite Follow-up |
Estimated Enrollment: | 300 |
Study Start Date: | August 2007 |
Estimated Study Completion Date: | August 2010 |
The purpose of this study is identify risk factors for signs and symptoms of osteoarthritis two year post ACL reconstruction from information available at the time of surgery; including patient characteristics (age, gender, body mass index (BMI), activity level, clinical knee alignment), their injuries ("pop" heard at the time of injury, concurrent meniscus, articular cartilage, and collateral ligament injuries), and treatment decisions made during the initial surgery (e.g. meniscus and articular cartilage treatments.)
Primary outcome measures will be the WOMAC pain and stiffness subscales and joint space width measured on weight-bearing radiographs.
Secondary outcome measures will include the knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS) and Kellgren-Lawrence grading from weight-bearing radiographs.
Ages Eligible for Study: | 12 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Participants enrolled in the Multicenter Orthopaedic Outcomes Network cohort by one of three surgeons and meeting eligibility criteria
Inclusion Criteria:
Exclusion Criteria:
United States, Ohio | |
Cleveland Clinic | |
Cleveland, Ohio, United States, 44195 | |
The Ohio State University | |
Columbus, Ohio, United States, 43221 | |
United States, Tennessee | |
Vanderbilt University | |
Nashville, Tennessee, United States, 37232 |
Principal Investigator: | Kurt P Spindler, M.D. | Vanderbilt University |
Responsible Party: | Vanderbilt University ( Kurt Spindler, MD ) |
Study ID Numbers: | 070264, RO1-AR53684-01A1 |
Study First Received: | May 24, 2007 |
Last Updated: | February 26, 2008 |
ClinicalTrials.gov Identifier: | NCT00478894 History of Changes |
Health Authority: | United States: Institutional Review Board; United States: Federal Government |
Anterior cruciate ligament / injuries Anterior cruciate ligament / surgery knee injuries / surgery |
outcomes research prospective studies osteoarthritis |
Musculoskeletal Diseases Osteoarthritis Joint Diseases |
Arthritis Knee Injuries Rheumatic Diseases |
Musculoskeletal Diseases Osteoarthritis Joint Diseases Arthritis Rheumatic Diseases |