fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease - Full Text View

Sponsors and Collaborators:	University of Wisconsin, Madison National Institutes of Health (NIH) National Institute on Aging (NIA)
Information provided by:	University of Wisconsin, Madison
ClinicalTrials.gov Identifier:	NCT00478491

Purpose

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Condition
Magnetic Resonance Imaging Alzheimer's Disease Dementia Adult Children Risk

Genetics Home Reference related topics: Alzheimer disease

MedlinePlus related topics: Alzheimer's Disease Dementia MRI Scans Memory

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Further study details as provided by University of Wisconsin, Madison:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

plasma and serum

Estimated Enrollment:	390
Study Start Date:	January 2003
Estimated Study Completion Date:	July 2009

Groups/Cohorts
1 Persons with a parent with Alzheimer's disease
2 Persons whose parents survived to old age without memory problems
3 Persons with diagnosed mild cognitive impairment
4 Persons without memory problems

Eligibility

Ages Eligible for Study:	40 Years to 85 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Persons with a parent with Alzheimer's disease will be recruited from the Wisconsin Registry for Alzheimer's Prevention (WRAP). Persons with MCI will be recruited from the UW clinics and satellite clinics. Controls for the above study groups will be recruited from the WRAP and the local community.

Criteria

Inclusion Criteria:

MCI Group: Diagnosis of mild cognitive impairment
AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria:

Claustrophobia
Metallic or electronic implants or devices that are not MRI-safe

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00478491

Locations

United States, Wisconsin
University of Wisconsin - Wisconsin Comprehensive Memory Program
Madison, Wisconsin, United States, 53792

Sponsors and Collaborators

University of Wisconsin, Madison

National Institutes of Health (NIH)

National Institute on Aging (NIA)

Investigators

Principal Investigator:

Sterling C Johnson, PhD

University of Wisconsin/VA GRECC

More Information

Additional Information:

Website for the Sterling Johnson Imaging Lab This link exits the ClinicalTrials.gov site

Website for the Wisconsin Comprehensive Memory Program This link exits the ClinicalTrials.gov site

Publications:

Ries ML, Jabbar BM, Schmitz TW, Trivedi MA, Gleason CE, Carlsson CM, Rowley HA, Asthana S, Johnson SC. Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal. J Int Neuropsychol Soc. 2007 May;13(3):450-61.

Johnson SC, Schmitz TW, Trivedi MA, Ries ML, Torgerson BM, Carlsson CM, Asthana S, Hermann BP, Sager MA. The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation. J Neurosci. 2006 May 31;26(22):6069-76.

Trivedi MA, Schmitz TW, Ries ML, Torgerson BM, Sager MA, Hermann BP, Asthana S, Johnson SC. Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study. BMC Med. 2006 Jan 13;4:1.

Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol. 2005 Dec 2;5:23.

Ries ML, Schmitz TW, Kawahara TN, Torgerson BM, Trivedi MA, Johnson SC. Task-dependent posterior cingulate activation in mild cognitive impairment. Neuroimage. 2006 Jan 15;29(2):485-92. Epub 2005 Aug 15.

Responsible Party:	University of Wisconsin - Madison ( Sterling Johnson, PhD )
Study ID Numbers:	2002-515, NIH RO1 AG021155A
Study First Received:	May 22, 2007
Last Updated:	November 8, 2008
ClinicalTrials.gov Identifier:	NCT00478491 History of Changes
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Alzheimer Disease
Central Nervous System Diseases
Neurodegenerative Diseases

Brain Diseases
Dementia
Cognition Disorders
Delirium

Additional relevant MeSH terms:

Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Nervous System Diseases
Alzheimer Disease
Central Nervous System Diseases

Neurodegenerative Diseases
Tauopathies
Brain Diseases
Dementia

ClinicalTrials.gov processed this record on May 07, 2009