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Sponsors and Collaborators: |
University of Wisconsin, Madison Department of Veterans Affairs |
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Information provided by: | University of Wisconsin, Madison |
ClinicalTrials.gov Identifier: | NCT00478166 |
The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate. Determining the functionality of this brain region may help us diagnose AD more accurately, thus allowing earlier treatment.
Condition |
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Magnetic Resonance Imaging Alzheimer's Disease Dementia Adult Children Risk |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease |
Estimated Enrollment: | 206 |
Study Start Date: | July 2005 |
Study Completion Date: | October 2007 |
The posterior cingulate is a key brain region suggested by recent studies to be affected in people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the course of AD and the region may have reduced function even prior to the onset of symptoms, further understanding of its functional role and its relationship to other brain regions may be helpful in detecting AD earlier and in monitoring disease progression and treatment.
This project examines the role of the PC and its connections to other brain regions using functional magnetic resonance imaging (fMRI), a technique that allows us to examine the brain at work during tests of memory and decision-making. The main goal is to see if functional connections between brain regions are modulated by risk for AD.
Ages Eligible for Study: | 55 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Wisconsin | |
University of Wisconsin - Wisconsin Comprehensive Memory Program | |
Madison, Wisconsin, United States, 53792 |
Principal Investigator: | Sterling C Johnson, PhD | University of Wisconsin/VA GRECC |
Responsible Party: | University of Wisconsin - Madison ( Sterling Johnson, PhD ) |
Study ID Numbers: | 2004-174 |
Study First Received: | May 22, 2007 |
Last Updated: | March 10, 2009 |
ClinicalTrials.gov Identifier: | NCT00478166 History of Changes |
Health Authority: | United States: Institutional Review Board; United States: Federal Government |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Alzheimer Disease Central Nervous System Diseases Neurodegenerative Diseases |
Brain Diseases Dementia Cognition Disorders Delirium |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Nervous System Diseases Alzheimer Disease Central Nervous System Diseases |
Neurodegenerative Diseases Tauopathies Brain Diseases Dementia |