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Sponsors and Collaborators: |
National Institute on Aging (NIA) National Center for Complementary and Alternative Medicine (NCCAM) |
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Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00118885 |
The purpose of this trial is to evaluate the effects of Tai Chi Chih versus Health Education on shingles immunity in older adults as measured by unstimulated and vaccine-stimulated responses. The secondary goal of the study is to determine the effects of Tai Chi Chih versus Health Education on measures of health functioning, depressive symptoms, and health behaviors in the elderly.
Condition | Intervention | Phase |
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Aging Herpes Zoster |
Behavioral: Tai Chi Chih |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Behavioral Intervention for Herpes Zoster Risk in Aging |
Estimated Enrollment: | 140 |
Study Start Date: | July 2001 |
Estimated Study Completion Date: | December 2004 |
Shingles, also known as herpes zoster (HZ), is more common in older persons due to the weakening of the immune system with advancing age. Psychosocial stresses in the older adult also correlate with the decline in immunity. In addition, preliminary data indicate that the presence of depressive symptoms in older adults is associated with a decline in the response to varicella zoster virus (VZV) vaccination. Taken together, the untoward effects of age and depressive symptoms on VZV immunity raise the question as to whether a behavioral intervention might augment VZV specific immunity in the older adult.
Preliminary data has shown that administration of a relaxation-response based intervention, Tai Chi Chih (TCC), results in improvements in health functioning and VZV immunity in older adults as compared to a control group. TCC is a slow moving meditation comprised of twenty separate standardized movements for use in elderly populations. By standardization of training and practice schedules, TCC offers an important advantage over prior relaxation response based therapies. This controlled trial has 3 goals:
Ages Eligible for Study: | 60 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute | |
Los Angeles, California, United States, 90095 |
Principal Investigator: | Michael R. Irwin, MD | Norman Cousins Professor, Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute |
Study ID Numbers: | AG0029, R01AG18367 |
Study First Received: | July 8, 2005 |
Last Updated: | November 8, 2006 |
ClinicalTrials.gov Identifier: | NCT00118885 History of Changes |
Health Authority: | United States: Federal Government |
Shingles depression varicella zoster virus alternative medicine psychoneuroimmunology |
Virus Diseases Herpes Zoster Depression Chickenpox |
DNA Virus Infections Depressive Disorder Varicella Zoster Herpesviridae Infections |
Virus Diseases Herpes Zoster DNA Virus Infections Herpesviridae Infections |