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Sponsors and Collaborators: |
National Health Research Institutes, Taiwan National Taiwan University Hospital Tri-Service General Hospital Chang Gung Memorial Hospital Cathay General Hospital Taipei Veterans General Hospital,Taiwan |
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Information provided by: | National Health Research Institutes, Taiwan |
ClinicalTrials.gov Identifier: | NCT00201370 |
The aims of this study are:
Condition |
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Cervical Cancer Low-Grade Squamous Intraepithelial Lesion, Human Papillomavirus |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | A Multi-Center Survey of HPV in Cervical Intraepithelial Neoplasia (CIN) With Longitudinal Follow-Up of LSIL Cases |
Estimated Enrollment: | 1000 |
Study Start Date: | August 1999 |
Estimated Study Completion Date: | November 2005 |
Carcinoma of the uterine cervix is by far the most prevalent cancer of women in Taiwan and worldwide. In 1994, it ranked the top of female cancer incidence with 3000 new cases annually and claimed nearly 1000 lives. The major cause of this malignant disease is now pointed to the infection of oncogenic types of human papillomavirus (HPV). HPV infection is sexually transmitted, affects the immature metaplastic cells of uterine cervix and, in an unknown proportion, results in squamous intraepithelial lesion (SIL) of differing severity. The natural history of HPV infection is by far elusive. It is not clear how the virus get into the cell, how the immune system respond to it, and how the epithelial cell get transformed. An average estimation holds that about 60% of low grade SIL will regress, 30% will persist, 10% will progress to high grade lesions and less than 1% become invasive lesions.
The aims of this study are:
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Taiwan | |
National Taiwan University Hospital | |
Taipei, Taiwan, 115 | |
Chang-Gung Memorial Hospital(Lin-Kou), | |
Taoyuan, Taiwan, 333 | |
Kaohsiung Medical University Hospital | |
Kaohsiung, Taiwan, 80708 | |
Veterans General Hospital-Taipei | |
Taipei, Taiwan, 112 | |
Tri-Services General Hospital | |
Taipei, Taiwan, 11490 |
Principal Investigator: | Tang-Yuan Chu, M.D., Ph.D. | Taiwan cooperative oncology group |
Study ID Numbers: | T1899 |
Study First Received: | September 14, 2005 |
Last Updated: | September 14, 2005 |
ClinicalTrials.gov Identifier: | NCT00201370 History of Changes |
Health Authority: | Taiwan: Department of Health |
cervical neoplasia; human papillomavirus, PCR, risk factors, Taiwan |
Genital Diseases, Female Uterine Cervical Diseases Precancerous Conditions Carcinoma in Situ Uterine Diseases |
Uterine Cervical Dysplasia Neoplasms, Glandular and Epithelial Carcinoma Cervical Intraepithelial Neoplasia |
Genital Diseases, Female Uterine Cervical Diseases Neoplasms Neoplasms by Histologic Type Precancerous Conditions Carcinoma in Situ |
Uterine Diseases Uterine Cervical Dysplasia Neoplasms, Glandular and Epithelial Carcinoma Cervical Intraepithelial Neoplasia |