Inclusion Criteria:

1. Ability to understand and willingness to sign a written informed consent
2. Informed consent signed by the patient
3. Age > 18 years old
4. Able to fulfill all criteria from the protocol
5. Performance status Karnofsky ≥ 60% (ECOG 0-2)
6. Life expectancy ≥ 12 weeks
7. Histologically or cytological (excluding endocrine pancreatic tumour), with metastatic (stage IV), following 6th edition of TNM classification
8. Measurable disease following RECIST criteria

9. Adequate bone marrow function as determined by:

   • Absolute Neutrophil account (ANC) ≥ 1,5 x 109/L
   • Platelets: ≥ 100 x 109/L
   • Hemoglobin: ≥ 9 g/dL.

10. Adequate liver function, as determined by:

    • Serum bilirubin (total): ≤ 1,5 x LSN
    • AST, ALT ≤ 2,5 x LSN in patients without liver metastasis. In patients with liver metastasis ≤ 5 x LSN

11. Adequate renal function, as determined by:

    • Clearance creatinine > 60.0 ml/min
12. Men or women potentially fertile (including postmenopausal women amenorrheic at least 24 months before the study) should use adequate contraceptive methods (oral contraceptives, intrauterine disposal, barrier methods together with spermicide or surgery sterilization)

Exclusion Criteria:

1. Local pancreatic cancer (stage IA-IIB) or locally advance cancer (stage III), following the TNM 6th edition classification. Patients with metastatic disease that relapse after the initial diagnosis of local or advance disease could be included in this study.
2. Evidence of medular compression, carcinomatosis meningitis or brain metastasis. In case of clinical suspicious of brain metastasis is mandatory to perform a brain TAC/MR 4 weeks prior inclusion.
3. Previous systemic treatment for metastasis pancreas cancer. Adjuvant chemotherapy is permitted ≥ 4 weeks prior de inclusion. All toxicities from the adjuvant treatment must been solve before the inclusion and should be confirmed the diseases progression (metastatic disease) alter adjuvant treatment
4. Primary tumours Developer 5 years previous to the inclusion, except in situ cérvix carcinoma or skin basocellular cancer properly treated

5. Non-controlled hypertension or cardiovascular disease clinically significant (active):

   • Cerebrovascular accident/ictus (≤ 6 weeks prior to inclusion)
   • Myocardial infart (≤ 6 months prior to inclusion)
   • Instable angina
   • Congestive cardiac insufficiency (grade II or superior following to New York Heart Association (NYHA)
   • Severe cardiac arrhythmia that require medication
6. Significant ophthalmology anomalies
7. Deficit in dihydropyrimidine dehydrogenase (DPD)
8. Unable to take oral drug. Previous surgical process that affect the absortion or make the needed to have intravenous feeding or parentheral nutrition with lipids.
9. Pregnancy women or in latency period. Negative pregnancy test needed 7 days prior to initiation drug study
10. Actual or 30 days previous to study treatment with other investigational drug or participation in other trial
11. Previous treatment with Capecitabine or EGFR inhibitor.
12. Any other disease, metabolic disease
13. Known hypersensibility to any study drug or any of their component, or to 5-fluorouracile