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Sponsored by: |
University of Zurich |
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Information provided by: | University of Zurich |
ClinicalTrials.gov Identifier: | NCT00450528 |
The purpose of this study is to investigate the natural kinetics of D-dimers that occur after abdominal surgery.
Condition |
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Natural Kicetics of d-Dimers After Surgery |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | The Kinetics of D-Dimers After Abdominal Surgery as a Function of the Invasiveness of Surgery |
Estimated Enrollment: | 90 |
Study Start Date: | February 2007 |
Study Completion Date: | October 2007 |
Venous thromboembolism (VTE) is a potentially fatal disease with an estimated incidence of 0.1%. One third of the VTE occur as pulmonal embolism with a mortality up to 25% (White RH. Circulation 107:2003)
Serum d-dimer levels are used as sensitive marker for the diagnosis of VTE (Kelly J et al. Arch Intern Med, 162: 2002). Because of its sensitivity, the determination of serum D-dimer levels is an accepted method to exclude VTE in the outpatient setting meaning that VTE may be excluded in case of normal D-dimer levels (Kelly J. Lancet 359: 2002). The specificity of the D-dimer testing, however, is low. This is true especially in the postoperative phase.
The interpretation of elevated D-dimer levels in surgical patients remains elusive.
The natural kinetics of D-dimers after surgery is not known. The question to what extent D-dimer levels rise after surgery and how long it may take D-dimer levels to return to normal after surgery is not yet determined. This information is needed to be able to use D-dimer testing for VTE diagnosis in surgical patients.
In this study, D-dimer levels are measured in surgical patients immediately before (day 0) and repeatedly after surgery. D-dimer level measurement will be stopped after D-dimer levels returned to normal.
Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Switzerland | |
Univeryity Hospital, Clinic for Visceral- and Transplantation Surgery | |
Zurich, Switzerland, 8091 |
Principal Investigator: | Daniel Dindo, MD | University of Zurich |
Study ID Numbers: | StV 31-2006 |
Study First Received: | March 21, 2007 |
Last Updated: | October 23, 2007 |
ClinicalTrials.gov Identifier: | NCT00450528 History of Changes |
Health Authority: | Switzerland: Federal Office of Public Health |
D-dimers surgery kinetics |
Fibrin fragment D |