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Sponsored by: |
Dresden University of Technology |
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Information provided by: | Dresden University of Technology |
ClinicalTrials.gov Identifier: | NCT00450268 |
We plan to investigate prospectively and simultaneously skin and blood DC subtypes, their donor/recipient origin and the correlation of DC reconstitution kinetics with treatment, clinical outcome and incidence of aGvHD in patients undergoing allogeneic hematopoietic stem cell transplantation.
Condition | Intervention |
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Graft Versus Host Disease |
Procedure: blood draw, skin shave biopsy |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Analysis of Dendritic Cells in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation |
Estimated Enrollment: | 50 |
Study Start Date: | January 2005 |
Estimated Study Completion Date: | January 2010 |
Blood and skin DC reconstitution shall be investigated in patients affected by hematological diseases and receiving HLA-matched, mobilized peripheral blood stem cells from related or unrelated donors. We plan to simultaneously collect and process double biopsies, i.e. from graft versus host disease affected and non-lesional skin of patients at onset of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation.
Emigration assay, Chimerism analysis and immunohistochemistry will be performed.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Susanne Gretzinger, MD | +49 351 458 ext 2583 | susanne.gretzinger@uniklinik-dresden.de |
Contact: Martin Bornhäuser, Professor | *49 351 458 ext 4190 | martin.bormhaeuser@uniklinik-dresden.de |
Germany | |
Universitätsklinik Carl Gustav Carus | Recruiting |
Dresden, Germany, 01307 | |
Contact: Susanne Gretzinger, MD +49 351 458 ext 2583 susanne.gretzinger@uniklinik-dresden.de | |
Contact: Martin Bornhaeuser, MD +49 351 458 ext 4190 Martin.Bornhaeuser@uniklinik-dresden.de | |
Principal Investigator: Susanne Gretzinger, MD | |
Principal Investigator: Martin Bornhaeuser, Prof | |
Principal Investigator: Christian Thiede, Prof |
Principal Investigator: | Susanne Gretzinger, MD | Universität Carl Gustav Carus Med Klinik I |
Study ID Numbers: | EK208122001 |
Study First Received: | March 21, 2007 |
Last Updated: | March 21, 2007 |
ClinicalTrials.gov Identifier: | NCT00450268 History of Changes |
Health Authority: | Germany: Ethics Commission |
Graft versus host disease Allogeneic hematpoietic stem cell transplantation |
Graft Versus Host Disease Graft vs Host Disease Homologous Wasting Disease |
Immune System Diseases Graft vs Host Disease |