Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects

This study has been completed.

First Received: April 3, 2006 Last Updated: March 30, 2007 History of Changes

Sponsored by:	Wyeth
Information provided by:	Wyeth
ClinicalTrials.gov Identifier:	NCT00311350

Purpose

This is the first multiple-dose experience in humans with MOA-728 in an oral formulation. This study will provide an assessment of the safety, tolerability, and pharmacokinetics (PK) of MOA-728 following administration of ascending multiple oral doses to healthy subjects.

Condition	Intervention	Phase
Postoperative Complications Constipation	Drug: MOA-728	Phase I

MedlinePlus related topics: Constipation

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Randomized, Double-Blind, Placebo Control, Safety Study
Official Title:	Ascending Multiple Dose Study of the Safety, Tolerability, and Pharmacokinetics of MOA-728 Administered Orally to Healthy Subjects

Further study details as provided by Wyeth:

Primary Outcome Measures:

Safety

Estimated Enrollment:	48
Study Start Date:	March 2006
Estimated Study Completion Date:	August 2006

Eligibility

Ages Eligible for Study:	18 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria: - Healthy men and women

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00311350

Locations

United States, Pennsylvania

Philadelphia, Pennsylvania, United States, 19148

Sponsors and Collaborators

Wyeth

Investigators

Study Director:

Medical Monitor

Wyeth

More Information

No publications provided

Study ID Numbers:	3200A3-100
Study First Received:	April 3, 2006
Last Updated:	March 30, 2007
ClinicalTrials.gov Identifier:	NCT00311350 History of Changes
Health Authority:	United States: Food and Drug Administration

Keywords provided by Wyeth:

Safety
Health
Pharmacokinetics
ileus

Study placed in the following topic categories:

Signs and Symptoms
Ileus
Signs and Symptoms, Digestive

Postoperative Complications
Constipation
Healthy

Additional relevant MeSH terms:

Signs and Symptoms
Pathologic Processes
Signs and Symptoms, Digestive
Postoperative Complications
Constipation

ClinicalTrials.gov processed this record on May 07, 2009