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Sponsored by: |
University Hospital, Gentofte, Copenhagen |
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Information provided by: | University Hospital, Gentofte, Copenhagen |
ClinicalTrials.gov Identifier: | NCT00311259 |
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
Condition | Intervention | Phase |
---|---|---|
Oxidative Stress Inflammatory Stress Myocardial Ischaemia |
Drug: Melatonin (drug) Drug: Laktose |
Phase II |
Study Type: | Observational |
Study Design: | Cross-Sectional, Random Sample, Prospective Study |
Estimated Enrollment: | 40 |
Study Start Date: | May 2006 |
Estimated Study Completion Date: | November 2006 |
Laparoscopic gall bladder surgery is connected with changes in the body resulting in cell damage and inflammation. Melatonin is a hormone produced in brain and regulate sleep rhythm, temperature, production of other hormones and function of organs. Furthermore melatonin can modify cell damage and inflammation. After surgery the production of melatonin is disturbed. The purpose of this study is therefore to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Bülent Kücükakin | +45 39978224 | bulkuc01@gentoftehosp.kbhamt.dk |
Denmark | |
Department of Surgical Gastroenterology, University Hospital of Copenhagen in Gentofte | |
Hellerup, Denmark, 2900 |
Principal Investigator: | Bülent Kücükakin | Department of Surgical Gastroenterology, University Hospital of Copenhagen in Gentofte |
Study ID Numbers: | 2612-3108 |
Study First Received: | April 3, 2006 |
Last Updated: | April 3, 2006 |
ClinicalTrials.gov Identifier: | NCT00311259 History of Changes |
Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Antioxidants Heart Diseases Myocardial Ischemia Vascular Diseases Central Nervous System Depressants |
Stress Melatonin Ischemia Inflammation |
Antioxidants Heart Diseases Molecular Mechanisms of Pharmacological Action Myocardial Ischemia Physiological Effects of Drugs Vascular Diseases Stress Central Nervous System Depressants |
Ischemia Protective Agents Pharmacologic Actions Pathologic Processes Therapeutic Uses Cardiovascular Diseases Melatonin Central Nervous System Agents |