Impact of Patient-Prosthesis-Mismatch on Coronary Flow Reserve

This study has been completed.

First Received: March 31, 2006 Last Updated: April 4, 2006 History of Changes

Sponsors and Collaborators:	Johann Wolfgang Goethe University Hospitals Medtronic
Information provided by:	Johann Wolfgang Goethe University Hospitals
ClinicalTrials.gov Identifier:	NCT00310947

Purpose

Complete normalization of CFR following AVR for aortic stenosis was observed only for stentless valves. Besides the superior hemodynamic performance this might explain the excellent long term results of this valve design.

Condition
Coronary Artery Disease

MedlinePlus related topics: Coronary Artery Disease

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Random Sample, Prospective Study
Official Title:	Impact of Patient-Prosthesis-Mismatch and Aortic Valve Design on Coronary Flow Reserve Following Aortic Valve Replacement

Further study details as provided by Johann Wolfgang Goethe University Hospitals:

Estimated Enrollment:	48
Study Start Date:	March 2005
Estimated Study Completion Date:	January 2006

Eligibility

Ages Eligible for Study:	18 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Aortic valve stenosis

Exclusion Criteria:

Coronary artery disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00310947

Locations

Germany, Hessen
JW Goethe University Ffm
Frankfurt am Main, Hessen, Germany, 60590

Sponsors and Collaborators

Johann Wolfgang Goethe University Hospitals

Medtronic

Investigators

Principal Investigator:

Peter Kleine, MD,PhD

JW Goethe University Ffm

More Information

No publications provided by Johann Wolfgang Goethe University Hospitals

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Bakhtiary F, Schiemann M, Dzemali O, Dogan S, Schachinger V, Ackermann H, Moritz A, Kleine P. Impact of patient-prosthesis mismatch and aortic valve design on coronary flow reserve after aortic valve replacement. J Am Coll Cardiol. 2007 Feb 20;49(7):790-6. Epub 2007 Feb 5.

Study ID Numbers:	Coronary flow reserve
Study First Received:	March 31, 2006
Last Updated:	April 4, 2006
ClinicalTrials.gov Identifier:	NCT00310947 History of Changes
Health Authority:	Germany: Ethics Commission

Keywords provided by Johann Wolfgang Goethe University Hospitals:

Coronary artery disease
Coronary flow reserve
Heart failure
prospective randomised

Study placed in the following topic categories:

Arterial Occlusive Diseases
Coronary Disease
Heart Failure
Heart Diseases
Myocardial Ischemia

Vascular Diseases
Arteriosclerosis
Ischemia
Coronary Artery Disease

Additional relevant MeSH terms:

Arterial Occlusive Diseases
Coronary Disease
Heart Diseases
Myocardial Ischemia

Vascular Diseases
Cardiovascular Diseases
Arteriosclerosis
Coronary Artery Disease

ClinicalTrials.gov processed this record on May 07, 2009