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Sponsors and Collaborators: |
Vanderbilt University California Transplant Donor Network University of California, San Francisco |
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Information provided by: | Vanderbilt University |
ClinicalTrials.gov Identifier: | NCT00310401 |
The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation, and increase the number of lungs available for transplantation, b) Developing a blood test to predict the development of primary graft dysfunction in lung transplant recipients, and c) treating brain dead organ donors with albuterol will decrease markers of primary graft dysfunction and lead to improved lung transplant recipient outcomes and to higher rates of lungs suitable for transplantation.
Condition | Intervention | Phase |
---|---|---|
Brain Death Organ Donor Pulmonary Edema |
Drug: Albuterol |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | The Effect of Nebulized Albuterol on Donor Oxygenation |
Estimated Enrollment: | 500 |
Study Start Date: | April 2007 |
Estimated Study Completion Date: | March 2011 |
Estimated Primary Completion Date: | March 2011 (Final data collection date for primary outcome measure) |
The donor lung utilization rate in the United States remains less than 15%, and the demand for donor lungs far exceeds the available supply. The most common reasons for failure to utilize donor lungs are donor hypoxemia and/or pulmonary infiltrates. Since pulmonary edema is a common, reversible cause of hypoxemia and infiltrates in patients with brain injury, strategies to treat pulmonary edema in organ donors should lead to improved donor oxygenation and higher rates of donor lung utilization. Inhaled beta-2 agonists increase the rate of alveolar fluid clearance and reduce pulmonary edema in both animal and human lungs. In addition, our group has recently reported that the majority of human donor lungs that are rejected for transplantation have measurable pulmonary edema and respond to beta-2 agonists with increased rates of alveolar fluid clearance. Based on this compelling scientific evidence, we propose to test the efficacy of an inhaled beta-2 agonist to increase the rate of alveolar fluid clearance and reduce pulmonary edema in brain dead organ donors with the following specific aims:
Specific Aim 1: To test the effect of aerosolized albuterol on donor oxygenation in a multicenter, randomized, double-blinded, placebo-controlled trial in 500 brain dead organ donors managed over a 2 year period by the California Transplant Donor Network (CTDN).
Hypothesis 1a: Treatment of brain dead organ donors with aerosolized albuterol will improve donor oxygenation and increase the donor lung utilization rate compared to treatment with placebo.
Hypothesis 1b: Treatment of brain dead organ donors with aerosolized albuterol will reduce the severity of pulmonary edema in procured lungs compared to treatment with placebo.
Specific Aim 2: To develop and validate a panel of biological markers that can predict and diagnose acute lung injury due to primary graft dysfunction in lung transplant recipients.
Hypothesis 2a: A panel of plasma biological markers measured in brain dead organ donors that includes markers of inflammation, coagulation, endothelial injury and lung epithelial injury will predict the development of primary graft dysfunction in the lung recipient.
Hypothesis 2b: Treatment of brain dead organ donors with inhaled beta-2 agonists will lead to reductions in levels of a panel of biological markers of inflammation, coagulation, endothelial injury, and lung epithelial injury that will be associated with increased donor lung utilization and improved recipient outcomes.
Ages Eligible for Study: | 14 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Contact: Lorraine B Ware, M.D. | 615-322-7828 | lorraine.ware@vanderbilt.edu |
Contact: Michael A Matthay, M.D. | 415-353-1210 | michael.matthay@ucsf.edu |
United States, California | |
California Transplant Donor Network | Recruiting |
Oakland, California, United States, 94612 |
Principal Investigator: | Lorraine B Ware, M.D. | Vanderbilt University |
Principal Investigator: | Michael A Matthay, M.D. | University of California, San Francisco |
Principal Investigator: | Megan Landeck, RN, BSN, APC | California Transplant Donor Network |
Responsible Party: | Vanderbilt University ( Lorraine B Ware, M.D. ) |
Study ID Numbers: | 3 UO1 HL081332-01S1 |
Study First Received: | March 1, 2006 |
Last Updated: | December 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00310401 History of Changes |
Health Authority: | United States: Institutional Review Board; United States: Food and Drug Administration |
brain death organ donor pulmonary edema albuterol |
hypoxia lung transplantation infiltrates |
Neurotransmitter Agents Death Unconsciousness Adrenergic beta-Agonists Adrenergic Agents Brain Death Albuterol Consciousness Disorders Anti-Asthmatic Agents Edema Central Nervous System Diseases |
Brain Diseases Adrenergic Agonists Coma Signs and Symptoms Pulmonary Edema Respiratory Tract Diseases Lung Diseases Neurologic Manifestations Peripheral Nervous System Agents Bronchodilator Agents Neurobehavioral Manifestations |
Respiratory System Agents Neurotransmitter Agents Death Molecular Mechanisms of Pharmacological Action Adrenergic Agents Albuterol Physiological Effects of Drugs Edema Reproductive Control Agents Brain Diseases Adrenergic Agonists Signs and Symptoms Pathologic Processes Tocolytic Agents Respiratory Tract Diseases |
Therapeutic Uses Neurobehavioral Manifestations Unconsciousness Adrenergic beta-Agonists Brain Death Consciousness Disorders Nervous System Diseases Central Nervous System Diseases Anti-Asthmatic Agents Pharmacologic Actions Coma Pulmonary Edema Autonomic Agents Lung Diseases Neurologic Manifestations |