Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
University of Illinois |
---|---|
Information provided by: | University of Illinois |
ClinicalTrials.gov Identifier: | NCT00846534 |
The purpose of the investigators study is to investigate the correlation between naturally occurring chemicals, called reactive oxygen species (ROS), in the blood of human patients and the development of an abnormal heart rhythm, known as atrial fibrillation (AF). The development of atrial fibrillation is associated with increased medical problems like stroke. Many factors seem to cause the development of AF, and this rhythm occurs frequently after open heart surgery. When patients develop AF after cardiac surgery they are at increased risk for cognitive changes, infections, the development of kidney failure, and increased length of hospitalization. ROS are chemicals in blood and tissues that tend to cause microscopic blood vessel and heart damage.
These chemicals occur naturally as the result of chemical reactions that occur in states of stress and inflammation, like tissue trauma and as the result of smoking. Patients who undergo cardiac surgery may have higher levels of ROS because of their underlying medical conditions. In addition, the organized tissue trauma that occurs in the setting of surgery may serve to increase ROS levels further. In turn, the higher ROS levels may put patients at even higher risk for the development of AF. The investigators believe that increased levels of ROS may help potentiate a patient's development of AF. Accordingly the investigators aim to measure ROS levels before and after surgery to see if there are particular levels that predict the development of this abnormal heart rhythm. By developing a better knowledge of the relationship between ROS and AF, the investigators hope to better understand another possible method of detecting patients who are at the highest risk of developing AF before it occurs after surgery. If these patients are better identified, this may eventually lead to medical treatment to prevent AF; and hopefully this will result in a decrease of the malicious effects that result from developing this abnormal heart rhythm.
Condition |
---|
Atrial Fibrillation |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | The Assessment of Oxidative Stress Markers and the Development of Atrial Fibrillation After Cardiac Surgery |
Approximately 10- 15 ml of blood will be drawn from subjects. Blood samples will be separated into plasma and serum to measure the oxidative stress markers.
Estimated Enrollment: | 8 |
Study Start Date: | April 2008 |
Estimated Study Completion Date: | December 2009 |
Groups/Cohorts |
---|
Post operative atrial fibrillation
To evaluate the ability of oxidative stress markers to predict postoperative atrial fibrillation in subjects undergoing cardiac surgery.
|
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
The target population of this study is all patients who will undergo cardiac surgery. There is no particular age range, but subjects less than 18 years of age will be omitted because of the rarity of AF in this population. The target number of subjects will be 100.
Inclusion Criteria:
Exclusion Criteria:
Contact: Irfan Shukrullah, MD | 3128390729 | irfans@uic.edu |
Contact: Dean Ferrera, DO | 3128390745 | dferrera@uic.edu |
United States, Illinois | |
University of Illinois at Chicago | Recruiting |
Chicago, Illinois, United States, 60612 | |
Contact: Irfan Shukrullah, MD 312-839-0729 irfans@uic.edu | |
Contact: Dean Ferrera, DO 3128390745 dferrera@uic.edu | |
Principal Investigator: Samuel C Dudley, MD,PhD |
Principal Investigator: | Samuel C Dudley, MD. PhD | University of Illinois |
Responsible Party: | University of Illinois at Chicago ( Dr. Samuel C. Dudely, Jr MD. PhD/ Professor of Medicine ) |
Study ID Numbers: | 2007-0916 |
Study First Received: | January 14, 2009 |
Last Updated: | February 17, 2009 |
ClinicalTrials.gov Identifier: | NCT00846534 History of Changes |
Health Authority: | United States: Institutional Review Board |
Oxidative stress markers Cardiac surgery Atrial Fibrillation |
Heart Diseases Stress Atrial Fibrillation Arrhythmias, Cardiac |
Pathologic Processes Heart Diseases Cardiovascular Diseases Atrial Fibrillation Arrhythmias, Cardiac |