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| Sponsored by: |
University College London Hospitals |
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| Information provided by: | University College London Hospitals |
| ClinicalTrials.gov Identifier: | NCT00662064 |
Purpose
The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated. This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.
| Condition |
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Urologic Diseases |
| Study Type: | Observational |
| Study Design: | Prospective |
| Official Title: | Pharmacology and Physiology of the Lower Urinary Tract |
bladder biopsies from patients with lower urinary tract dysfunction and from healthy controls
| Estimated Enrollment: | 200 |
| Study Start Date: | February 2002 |
| Estimated Study Completion Date: | December 2008 |
| Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
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1
Patients with lower urinary tract dysfunction
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2
Controls with normal lower urinary tract function
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Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Patients with lower urinary tract dysfunction and controls with normal lower urinary tract function
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Thomas M Kessler, MD | 44-207-829-8713 ext 8713 | tkessler@gmx.ch |
| Contact: Shahid Khan, MD | 44-207-829-8713 ext 8713 | drshahidkhan@gmail.com |
| United Kingdom | |
| Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery | Recruiting |
| London, United Kingdom, WC1N 3BG | |
| Contact: Thomas M Kessler, MD 44-207-829-8713 ext 8713 tkessler@gmx.ch | |
| Contact: Shahid Khan, MD 44-207-829-8713 ext 8713 drshahidkhan@gmail.com | |
| Principal Investigator: Clare J Fowler, FRCP | |
| Principal Investigator: | Clare J Fowler, FRCP | Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK |
| Principal Investigator: | Suzy Elneil, PhD, MRCOG | Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK |
More Information
| Responsible Party: | Dep Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK ( Prof C J Fowler, Prof C H Fry ) |
| Study ID Numbers: | 00/0039 |
| Study First Received: | April 16, 2008 |
| Last Updated: | June 19, 2008 |
| ClinicalTrials.gov Identifier: | NCT00662064 History of Changes |
| Health Authority: | United Kingdom: National Health Service |
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Lower urinary tract Physiology Pathology Immunohistochemistry Urinary bladder |
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Urologic Diseases |
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Urologic Diseases |
