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Sponsors and Collaborators: |
Weill Medical College of Cornell University Cervical Spine Research Society |
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Information provided by: | Weill Medical College of Cornell University |
ClinicalTrials.gov Identifier: | NCT00280306 |
White matter fiber tracking may provide a novel tool to assess the integrity of injured motor tracts in the cervical spine. It provides information about fiber directions which is not given by conventional MRI. White matter fiber tracking in the brain is used at several institutions, including our own medical college, for presurgical planning of tumor excision. We believe that the technical and clinical experience gained for the brain can be applied to fiber tracking in the cervical spine as well.
Condition |
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Spinal Cord Compression |
Study Type: | Observational |
Study Design: | Case Control, Cross-Sectional |
Official Title: | White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord - Pilot Study |
Estimated Enrollment: | 35 |
Study Start Date: | November 2005 |
Estimated Study Completion Date: | October 2008 |
Estimated Primary Completion Date: | October 2008 (Final data collection date for primary outcome measure) |
White matter fiber tracking may provide a novel tool to assess the integrity of injured motor tracts in the cervical spine. It provides information about fiber directions which is not given by conventional MRI. White matter fiber tracking in the brain is used at several institutions, including our own medical college, for presurgical planning of tumor excision. We believe that the technical and clinical experience gained for the brain can be applied to fiber tracking in the cervical spine as well. White matter fiber tracking in the cervical spine has some important clinical applications:
We will first study a pool of 15 normal control subjects to refine our data acquisition and postprocessing tools, and to sample quantitative diffusion based data for the normal cervical spine. A second group of subjects will include 10 patients with significant cervical spondylosis and upper extremity radiculopathy without myelopathy. The third group will be 10 patients with cervical spondylosis and signs and symptoms of myelopathy. The two patient groups will allow us to define systematic differences between normal values and values in the injured spine.
The DTI data will be processed using tools for artifact correction first and then tools for rendering T2 weighted images, diffusion weighted images, ADC maps and FA values.
Ages Eligible for Study: | 21 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Cervical spinal cord compression
Inclusion Criteria:
Normal controls Spinal cord injury
Exclusion Criteria:
N/A
United States, New York | |
Weill Medical College of Cornell | |
New York, New York, United States, 10021 |
Principal Investigator: | Henning U Voss | Weill Medical College of Cornell |
Responsible Party: | Weill Cornell Medical College ( Henning U. Voss, PhD, Assistant Professor of Physics in Radiology ) |
Study ID Numbers: | 1-Voss |
Study First Received: | January 17, 2006 |
Last Updated: | March 20, 2008 |
ClinicalTrials.gov Identifier: | NCT00280306 History of Changes |
Health Authority: | United States: Institutional Review Board |
Spinal Cord Injuries Spinal Cord Diseases Spinal Cord Compression |
Wounds and Injuries Disorders of Environmental Origin Central Nervous System Diseases |
Spinal Cord Injuries Spinal Cord Diseases Spinal Cord Compression Nervous System Diseases |
Wounds and Injuries Disorders of Environmental Origin Central Nervous System Diseases |