Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
University Hospital, Tours |
---|---|
Information provided by: | University Hospital, Tours |
ClinicalTrials.gov Identifier: | NCT00241306 |
The purpose of this study is to determine whether gender and age modify cerebral activations during a silent word generation functional Magnetic Resonance task.
Condition |
---|
Aging |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Variations of Hemispheric Lateralisation of Language Depending of Gender and Age. |
Introduction : The theory of a bipolar organization of language was revised in the light of neuroimaging results and language seems to be processed in a large scale cognitive network. The organization and function of this neural network may be modified by several factors including gender and age. There is some controversy about sex differences in language according to behavioural and neuroimaging studies :
Age differences were mainly studied in childhood, but no consistent functional imaging data on aging are available.
Objective : To study the influence of gender and age on cortical fMRI activations during a silent semantic task.
Subjects : 48 right-handed native French-speaking subjects were included in 4 groups of 12 according to age and gender : young female (YF), Young Male (YM), Old Female (OF), and Old Male (OM). Old subjects had no Alzheimer's disease or other dementia according to their MMS score (> 26) and NINCDS-ADRDA criteria.
Method :
Data were analyzed using the FSFAST package. MR data were motion corrected using AFNI and then smoothed with a FWHM of 5 mm. The voxel intensities were rescaled such that the in-brain grand mean was 1000 for all subjects. The hemodynamic response was modeled as a gamma function (delay : 2.25 s - dispersion :1.25 s). The offset and linear drift in the BOLD signal were removed by estimating those components simultaneously with the amplitude of the hemodynamic response. A t-test was then performed on the amplitude of the hemodynamic response to determine which voxels had significant paradigm-related activity.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Extra inclusion criteria for old subjects:
Exclusion Criteria:
Study ID Numbers: | PHRC-R2001 |
Study First Received: | October 14, 2005 |
Last Updated: | October 14, 2005 |
ClinicalTrials.gov Identifier: | NCT00241306 History of Changes |
Health Authority: | France: Ministry of Health |
aging language gender |