Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

This study has been completed.

First Received: March 5, 2007 No Changes Posted

Sponsored by:	Mayo Clinic
Information provided by:	Mayo Clinic
ClinicalTrials.gov Identifier:	NCT00443716

Purpose

To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens collected from subjects recruited in the study (IRB number 21B85). The adipocytic parameters will be then correlated with osteoblastic parameters obtained previously during the course of the initai study involving the effect of transdermal estrogen on bone turnover in postmenopausal osteoporotic women.

Condition	Intervention
Osteoporosis Postmenopausal	Drug: estrogen

MedlinePlus related topics: Menopause Osteoporosis

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Placebo Control, Parallel Assignment, Efficacy Study
Official Title:	Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:

efficacy of estraderm treatment on osteoporotic women

Estimated Enrollment:	60
Study Start Date:	April 1985
Estimated Study Completion Date:	April 1989

Eligibility

Ages Eligible for Study:	30 Years and older
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Post-menopausal osteoporotic women

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00443716

Locations

United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905

Sponsors and Collaborators

Mayo Clinic

Investigators

Principal Investigator:

B. Lawrence Riggs, M.D.

Mayo Clinic

More Information

No publications provided

Study ID Numbers:	05-004111, 21b85
Study First Received:	March 5, 2007
Last Updated:	March 5, 2007
ClinicalTrials.gov Identifier:	NCT00443716 History of Changes
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Estrogens
Musculoskeletal Diseases
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Osteoporosis

Bone Diseases, Metabolic
Hormones
Bone Diseases
Menopause

Additional relevant MeSH terms:

Estrogens
Musculoskeletal Diseases
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Osteoporosis

Bone Diseases, Metabolic
Hormones
Bone Diseases
Pharmacologic Actions

ClinicalTrials.gov processed this record on May 07, 2009